{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T07:51:33Z","timestamp":1766908293767},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T00:00:00Z","timestamp":1289347200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The tapeworm <jats:italic>Ligula<\/jats:italic><jats:italic>intestinalis<\/jats:italic> commonly infests roach (<jats:italic>Rutilus<\/jats:italic><jats:italic>rutilus<\/jats:italic>) and is responsible for the inhibition of gonad development. In order to better understand the effect of the plerocercoid on fish physiology, and to discriminate parasitization effects from those of endocrine-disrupting compounds (EDC), <jats:italic>Cyp19b<\/jats:italic> and <jats:italic>Cyp19a<\/jats:italic> aromatase expression was investigated by real-time quantitative polymerase chain reaction (PCR) in brain and gonads of ligulosed roach, caught from a reference site. Data were compared to reproductive and endocrine endpoints previously reported in a larger cohort study (including the sampled population of the present one), such as gonadosomatic index, Fulton index, gonadal histology, plasma sex steroid levels and brain aromatase activity. A decrease in <jats:italic>Cyp19b<\/jats:italic> expression in the brain of infected fish was demonstrated, in agreement with the reduction of aromatase activity previously described. In contrast, <jats:italic>Cyp19a<\/jats:italic> expression in the gonads appeared to be enhanced in ligulosed fish, in accordance with the presence of immature but differentiated sexual tissues. Together these results show that: (1) <jats:italic>L. intestinalis<\/jats:italic> infestation results in an alteration of aromatase expression which, in particular, may have profound effects on the fish brain; and (2) <jats:italic>L. intestinalis<\/jats:italic> infection must be considered as a major confounding factor in ecotoxicological studies using aromatase expression as an EDC biomarker. Moreover, the concordance between activity and expression \u2013 investigated for the first time in the same population \u2013 gives a functional relevance to the transcript aromatase dosage in the brain. Finally, quantitative PCR was confirmed as a sensitive approach, enabling aromatase status to be defined in the poorly developed gonads of ligulosed individuals.<\/jats:p>","DOI":"10.1017\/s0022149x10000660","type":"journal-article","created":{"date-parts":[[2010,11,10]],"date-time":"2010-11-10T11:27:14Z","timestamp":1289388434000},"page":"339-344","source":"Crossref","is-referenced-by-count":6,"title":["<i>Ligula<\/i><i>intestinalis<\/i> infection is associated with alterations of both brain and gonad aromatase expression in roach (<i>Rutilus<\/i><i>rutilus<\/i>)"],"prefix":"10.1017","volume":"85","author":[{"given":"C.","family":"Boulange-Lecomte","sequence":"first","affiliation":[]},{"given":"P.","family":"Geraudie","sequence":"additional","affiliation":[]},{"given":"J.","family":"Forget-Leray","sequence":"additional","affiliation":[]},{"given":"M.","family":"Gerbron","sequence":"additional","affiliation":[]},{"given":"C.","family":"Minier","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2010,11,10]]},"reference":[{"key":"S0022149X10000660_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.04.011"},{"key":"S0022149X10000660_ref18","first-page":"801","article-title":"An investigation of the incidence of intersex fish in Seine-Maritime and Sussex regions","volume":"28","author":"Minier","year":"2000","journal-title":"Analysis"},{"key":"S0022149X10000660_ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2427.2001.00733.x"},{"key":"S0022149X10000660_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182001008538"},{"key":"S0022149X10000660_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003003652"},{"key":"S0022149X10000660_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182010000107"},{"key":"S0022149X10000660_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-2-r19"},{"key":"S0022149X10000660_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2004.12.008"},{"key":"S0022149X10000660_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-009-9351-5"},{"key":"S0022149X10000660_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200999151X"},{"key":"S0022149X10000660_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2010.01.003"},{"key":"S0022149X10000660_ref4","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00742"},{"key":"S0022149X10000660_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.05.003"},{"key":"S0022149X10000660_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icm057"},{"key":"S0022149X10000660_ref2","doi-asserted-by":"publisher","DOI":"10.2307\/3276934"},{"key":"S0022149X10000660_ref21","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2008153434"},{"key":"S0022149X10000660_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(01)00147-9"},{"key":"S0022149X10000660_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2006.05.046"},{"key":"S0022149X10000660_ref1","first-page":"265","article-title":"Ligula intestinalis \u2013 a tapeworm contraceptive","volume":"49","author":"Arme","year":"2002","journal-title":"Biologist (London)"},{"key":"S0022149X10000660_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.08.010"},{"key":"S0022149X10000660_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2007.03.005"},{"key":"S0022149X10000660_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.03.002"},{"key":"S0022149X10000660_ref24","first-page":"235","article-title":"The roach (Rutilus rutilus) as a sentinel for assessing endocrine disruption","volume":"14","author":"Tyler","year":"2007","journal-title":"Environmental Sciences"},{"key":"S0022149X10000660_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/212736a0"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X10000660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T06:37:40Z","timestamp":1556347060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X10000660\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,10]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0022149X10000660"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x10000660","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,10]]}}}