{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:59:27Z","timestamp":1776211167663,"version":"3.50.1"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T00:00:00Z","timestamp":1214352000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221510800279X_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Phenotypical Down syndrome includes pharyngeal and maxillary hypoplasia and, frequently, constricted maxillary arch with nasal obstruction.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510800279X_sec2\"><jats:title>Study design:<\/jats:title><jats:p>This clinical trial assessed the effects of rapid maxillary expansion on ENT disorders in 24 children with Down syndrome randomly allocated to receive either rapid maxillary expansion or not. Each group received ENT and speech therapy assessments before expansion and after the device had been removed.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510800279X_sec3\"><jats:title>Results:<\/jats:title><jats:p>In the rapid maxillary expansion group, the yearly ENT infection rate was reduced when assessed after device removal (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The parents of rapid maxillary expansion children reported a reduction in respiratory obstruction symptoms. Audiological assessment revealed improvements in the rapid maxillary expansion group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Cephalometry showed increased maxillary width in the rapid maxillary expansion group.<\/jats:p><\/jats:sec><jats:sec id=\"S002221510800279X_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>Rapid maxillary expansion resulted in a reduction in hearing loss, yearly rate of ENT infections and parentally assessed symptoms of upper airway obstruction, compared with no treatment. These findings are probably related to expanded oronasal space, due to rapid maxillary expansion.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221510800279x","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T08:53:55Z","timestamp":1214470435000},"page":"1318-1324","source":"Crossref","is-referenced-by-count":43,"title":["Down syndrome: otolaryngological effects of rapid maxillary expansion"],"prefix":"10.1017","volume":"122","author":[{"given":"C Pinto","family":"de Moura","sequence":"first","affiliation":[]},{"given":"D","family":"Andrade","sequence":"additional","affiliation":[]},{"given":"L M","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"M J","family":"Tavares","sequence":"additional","affiliation":[]},{"given":"M J","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"P","family":"Vaz","sequence":"additional","affiliation":[]},{"given":"H","family":"Barros","sequence":"additional","affiliation":[]},{"given":"S M","family":"Pueschel","sequence":"additional","affiliation":[]},{"given":"M","family":"Pais Clemente","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2008,6,25]]},"reference":[{"key":"S002221510800279X_ref17","first-page":"118","article-title":"Does the timing and method of rapid maxillary expansion have an effect on the changes in nasal dimensions?","volume":"72","author":"Basciftci","year":"2002","journal-title":"Angle Orthod"},{"key":"S002221510800279X_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9416(80)90129-3"},{"key":"S002221510800279X_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100080804"},{"key":"S002221510800279X_ref12","unstructured":"12 Ricketts RM , Roth RH , Chaconas SJ , Schulhof RJ , Engel GA . 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