{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:53:55Z","timestamp":1767084835307},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T00:00:00Z","timestamp":1242000000000},"content-version":"unspecified","delay-in-days":6219,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Mar. Biol. Ass."],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:p>Cadmium uptake, storage and metabolism has been studied in the digestive gland and remaining tissues of the intertidal gastropod <jats:italic>Littorina littorea<\/jats:italic> (L). Accumulation of cadmium was linear with time in both of these compartments in individuals exposed to a range of cadmium concentrations (4, 40 and 400 \u03bcg Cd l<jats:sup>\u22121<\/jats:sup>).<\/jats:p><jats:p>The subcellular distribution of cadmium in the digestive gland and remaining tissues of <jats:italic>Littorina littorea<\/jats:italic> reveals that most of the metal is bound to metallothionein, even in controls, and that cadmium associated with metallothionein increases in proportion to cadmium concentrations in the surrounding water.<\/jats:p><jats:p>Measurements of metallothionein, made by differential pulse polarography showed that, in the digestive gland, concentrations of this metal-binding protein are not significantly affected by cadmium exposure, while in the remaining tissues they are dose-related.<\/jats:p><jats:p>The inherently high levels of metallothionein in the digestive gland of <jats:italic>L. littorea<\/jats:italic> explain the role of this tissue as a major site for cadmium storage. However, the lack of significant <jats:italic>de novo<\/jats:italic> synthesis of metallothionein in response to cadmium, together with polarographic interferences from high molecular weight thiolic proteins, reduces the value of this tissue preparation as a means of detecting sublethal responses to metals.<\/jats:p>","DOI":"10.1017\/s0025315400037735","type":"journal-article","created":{"date-parts":[[2009,5,12]],"date-time":"2009-05-12T15:38:01Z","timestamp":1242142681000},"page":"329-342","source":"Crossref","is-referenced-by-count":51,"title":["Metallothionein induction in <i>Littorina littorea<\/i> (Mollusca: Prosobranchia) on exposure to cadmium"],"prefix":"10.1017","volume":"72","author":[{"given":"M.J.","family":"Bebianno","sequence":"first","affiliation":[]},{"given":"W.J.","family":"Langston","sequence":"additional","affiliation":[]},{"given":"K.","family":"Simkiss","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2009,5,11]]},"reference":[{"key":"S0025315400037735_ref022","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1139\/f88-148","volume":"45","author":"Roesijadi","year":"1988","journal-title":"Canadian Journal of Fisheries and Aquatic 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