{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:12:49Z","timestamp":1773807169097,"version":"3.50.1"},"reference-count":64,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T00:00:00Z","timestamp":1511222400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Temperature is expected to modulate the responses of organisms to stress. Here, we aimed to assess the influence of temperature on the interaction between parasitism and fungicide contamination. Specifically, using the cladoceran <jats:italic>Daphnia<\/jats:italic> as a model system, we explored the isolated and interactive effects of parasite challenge (yeast <jats:italic>Metschnikowia bicuspidata<\/jats:italic>) and exposure to fungicides (copper sulphate and tebuconazole) at two temperatures (17 and 20 \u00b0C), in a fully factorial design. Confirming a previous study, <jats:italic>M. bicuspidata<\/jats:italic> infection and copper exposure caused independent effects on <jats:italic>Daphnia<\/jats:italic> life history, whereas infection was permanently suppressed with tebuconazole exposure. Here, we show that higher temperature generally increased the virulence of the parasite, with the hosts developing signs of infection earlier, reproducing less and dying at an earlier age. These effects were consistent across copper concentrations, whereas the joint effects of temperature (which enhanced the difference between non-infected and infected hosts) and the anti-parasitic action of tebuconazole resulted in a more pronounced parasite \u00d7 tebuconazole interaction at the higher temperature. Thus, besides independently influencing parasite and contaminant effects, the temperature can act as a modulator of interactions between pollution and disease.<\/jats:p>","DOI":"10.1017\/s0031182017002062","type":"journal-article","created":{"date-parts":[[2017,11,21]],"date-time":"2017-11-21T05:09:38Z","timestamp":1511240978000},"page":"939-947","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["Temperature modulates the interaction between fungicide pollution and disease: evidence from a <i>Daphnia<\/i>-microparasitic yeast model"],"prefix":"10.1017","volume":"145","author":[{"given":"Ana P.","family":"Cuco","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-6061","authenticated-orcid":false,"given":"Bruno B.","family":"Castro","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"Justyna","family":"Wolinska","sequence":"additional","affiliation":[]},{"given":"Nelson","family":"Abrantes","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2017,11,21]]},"reference":[{"key":"S0031182017002062_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2435.2011.01872.x"},{"key":"S0031182017002062_ref8","doi-asserted-by":"publisher","DOI":"10.1890\/0012-9658(2006)87[1438:PSOLCE]2.0.CO;2"},{"key":"S0031182017002062_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.funeco.2015.03.007"},{"key":"S0031182017002062_ref53","doi-asserted-by":"publisher","DOI":"10.2307\/1938671"},{"key":"S0031182017002062_ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s00265-013-1634-2"},{"key":"S0031182017002062_ref17","doi-asserted-by":"publisher","DOI":"10.1201\/b19652"},{"key":"S0031182017002062_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2427.2012.02846.x"},{"key":"S0031182017002062_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2014.09.030"},{"key":"S0031182017002062_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2007.00072.x"},{"key":"S0031182017002062_ref9","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2012.0684"},{"key":"S0031182017002062_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbr.2015.03.002"},{"key":"S0031182017002062_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0706.2008.17028.x"},{"key":"S0031182017002062_ref62","doi-asserted-by":"publisher","DOI":"10.1093\/plankt\/fbr016"},{"key":"S0031182017002062_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2013.01.066"},{"key":"S0031182017002062_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.funeco.2015.06.004"},{"key":"S0031182017002062_ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s00442-011-1905-4"},{"key":"S0031182017002062_ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2009.02.004"},{"key":"S0031182017002062_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2012.04.020"},{"key":"S0031182017002062_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.01.079"},{"key":"S0031182017002062_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1364-3703.2011.00783.x"},{"key":"S0031182017002062_ref43","doi-asserted-by":"publisher","DOI":"10.1086\/599080"},{"key":"S0031182017002062_ref40","volume-title":"Climate Change 2014: Synthesis Report. Contribution of Working Groups I, II and III to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change","year":"2014"},{"key":"S0031182017002062_ref50","first-page":"467","article-title":"The impact of climate change on the parasites and infectious diseases of aquatic animals","volume":"27","author":"Marcogliese","year":"2008","journal-title":"Revue scientifique et technique (International Office of Epizootics)"},{"key":"S0031182017002062_ref46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2664.2010.01791.x"},{"key":"S0031182017002062_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10452-012-9397-9"},{"key":"S0031182017002062_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/czoolo\/59.3.427"},{"key":"S0031182017002062_ref59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1420-9101.2008.01555.x"},{"key":"S0031182017002062_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2013.04.014"},{"key":"S0031182017002062_ref44","doi-asserted-by":"publisher","DOI":"10.1021\/es8009309"},{"key":"S0031182017002062_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1461-0248.2006.00995.x"},{"key":"S0031182017002062_ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-4566-8"},{"key":"S0031182017002062_ref23","volume-title":"Ecology, Epidemiology, and Evolution of Parasitism in Daphnia","author":"Ebert","year":"2005"},{"key":"S0031182017002062_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.13095"},{"key":"S0031182017002062_ref2","first-page":"1","article-title":"Nectar yeasts of the Metschnikowia clade are highly susceptible to azole antifungals widely used in medicine and agriculture","volume":"16","author":"\u00c1lvarez-P\u00e9rez","year":"2015","journal-title":"FEMS Yeast Research"},{"key":"S0031182017002062_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.agee.2011.10.010"},{"key":"S0031182017002062_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-010-0024-y"},{"key":"S0031182017002062_ref5","doi-asserted-by":"publisher","DOI":"10.4319\/lo.1969.14.5.0693"},{"key":"S0031182017002062_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-016-1689-8"},{"key":"S0031182017002062_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172589"},{"key":"S0031182017002062_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.2539"},{"key":"S0031182017002062_ref20","doi-asserted-by":"publisher","DOI":"10.1890\/08-1130.1"},{"key":"S0031182017002062_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/1365-2435.12197"},{"key":"S0031182017002062_ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00062"},{"key":"S0031182017002062_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/srep35039"},{"key":"S0031182017002062_ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s00442-012-2452-3"},{"key":"S0031182017002062_ref35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043573"},{"key":"S0031182017002062_ref37","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6785-12-12"},{"key":"S0031182017002062_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2009.10.067"},{"key":"S0031182017002062_ref42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707763104"},{"key":"S0031182017002062_ref47","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2005.3310"},{"key":"S0031182017002062_ref48","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182010000296"},{"key":"S0031182017002062_ref49","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1128\/AAC.42.11.3018","article-title":"Organism-dependent fungicidal activities of azoles","volume":"42","author":"Manavathu","year":"1998","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"S0031182017002062_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.11.002"},{"key":"S0031182017002062_ref18","doi-asserted-by":"publisher","DOI":"10.1086\/528998"},{"key":"S0031182017002062_ref52","volume-title":"Population Parameters: Estimation for Ecological Models","author":"McCallum","year":"2000"},{"key":"S0031182017002062_ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2005.tb00895.x"},{"key":"S0031182017002062_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2009.02.006"},{"key":"S0031182017002062_ref64","doi-asserted-by":"publisher","DOI":"10.1787\/9789264185203-en"},{"key":"S0031182017002062_ref57","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2010.0616"},{"key":"S0031182017002062_ref38","doi-asserted-by":"publisher","DOI":"10.1080\/20014091111695"},{"key":"S0031182017002062_ref61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2009.00663.x"},{"key":"S0031182017002062_ref63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.2011.01240.x"},{"key":"S0031182017002062_ref32","doi-asserted-by":"publisher","DOI":"10.1890\/08-0838.1"},{"key":"S0031182017002062_ref31","doi-asserted-by":"publisher","DOI":"10.1890\/0012-9658(2006)87[1684:WDNHTM]2.0.CO;2"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182017002062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T15:58:02Z","timestamp":1555257482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182017002062\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,21]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0031182017002062"],"URL":"https:\/\/doi.org\/10.1017\/s0031182017002062","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,21]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2017\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}