{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:17:54Z","timestamp":1767827874544,"version":"3.49.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Cardiol Young"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1047951116002560_abs1\" sec-type=\"general\"><jats:title>Background<\/jats:title><jats:p>Bicuspid aortic valve is the most common CHD. Its association with early valvular dysfunction, endocarditis, thoracic aorta dilatation, and aortic dissection is well established.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951116002560_abs2\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess the incidence and predictors of cardiac events in adults with bicuspid aortic valve.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951116002560_abs3\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>We carried out a retrospective analysis of cardiac outcomes in ambulatory adults with bicuspid aortic valve followed-up in a tertiary hospital centre. Outcomes were defined as follows: interventional \u2013 intervention on the aortic valve or thoracic aorta; medical \u2013 death, aortic dissection, aortic valve endocarditis, congestive heart failure, arrhythmias, or ischaemic heart disease requiring hospital admission; and a composite end point of both. Kaplan\u2013Meier curves were generated to determine event rates, and predictors of cardiac events were determined by multivariate analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S1047951116002560_abs4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A total of 227 patients were followed-up over 13\u00b19 years; 29% of patients developed severe aortic valve dysfunction and 12.3% reached ascending thoracic aorta dimensions above 45 mm. At least one cardiac outcome occurred in 38.8% of patients, with an incidence rate at 20 years of follow-up of 47\u00b14%; 33% of patients were submitted to an aortic valve or thoracic aorta intervention. Survival 20 years after diagnosis was 94\u00b12%. Independent predictors of the composite end point were baseline moderate\u2013severe aortic valve dysfunction (hazard ratio, 3.19; 95% confidence interval, 1.35\u20137.54; p&lt;0.01) and aortic valve leaflets calcification (hazard ratio, 4.72; 95% confidence interval, 1.91\u201311.64; p&lt;0.005).<\/jats:p><\/jats:sec><jats:sec id=\"S1047951116002560_abs5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>In this study of bicuspid aortic valve, the long-term survival was excellent but with occurrence of frequent cardiovascular events. Baseline aortic valve calcification and dysfunction were the only independent predictors of events.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1047951116002560","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T04:21:19Z","timestamp":1481516479000},"page":"518-529","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":37,"title":["Bicuspid aortic valve outcomes"],"prefix":"10.1017","volume":"27","author":[{"given":"In\u00eas","family":"Rodrigues","sequence":"first","affiliation":[]},{"given":"Ana F.","family":"Agapito","sequence":"additional","affiliation":[]},{"given":"L\u00eddia","family":"de Sousa","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 A.","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Lu\u00edsa M.","family":"Branco","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Galrinho","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"Abreu","sequence":"additional","affiliation":[]},{"given":"Ana T.","family":"Tim\u00f3teo","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia A.","family":"Rosa","sequence":"additional","affiliation":[]},{"given":"Rui C.","family":"Ferreira","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"S1047951116002560_ref22","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015343.76143.13"},{"key":"S1047951116002560_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.10.036"},{"key":"S1047951116002560_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007851"},{"key":"S1047951116002560_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304606"},{"key":"S1047951116002560_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1317"},{"key":"S1047951116002560_ref27","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304920"},{"key":"S1047951116002560_ref25","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.189050"},{"key":"S1047951116002560_ref23","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.1.81"},{"key":"S1047951116002560_ref26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1286"},{"key":"S1047951116002560_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2005.06.002"},{"key":"S1047951116002560_ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.suppl_3.III-35"},{"key":"S1047951116002560_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"S1047951116002560_ref2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.1.81"},{"key":"S1047951116002560_ref8","volume-title":"Textbook of Clinical Echocardiography","author":"Otto","year":"2013"},{"key":"S1047951116002560_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00563-3"},{"key":"S1047951116002560_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(82)90233-2"},{"key":"S1047951116002560_ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.740878"},{"key":"S1047951116002560_ref10","doi-asserted-by":"publisher","DOI":"10.4250\/jcu.2015.23.1.1"},{"key":"S1047951116002560_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"S1047951116002560_ref28","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0b013e31819f9369"},{"key":"S1047951116002560_ref6","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1093\/eurheartj\/ehs109","article-title":"Guidelines on the management of valvular heart disease (version 2012)","volume":"33","author":"Vahanian","year":"2012","journal-title":"Eur Heart J"},{"key":"S1047951116002560_ref24","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.032128"},{"key":"S1047951116002560_ref15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155623.48408.C5"},{"key":"S1047951116002560_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.4.744"},{"key":"S1047951116002560_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1369"},{"key":"S1047951116002560_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00462-4"},{"key":"S1047951116002560_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960280303"},{"key":"S1047951116002560_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(03)01249-9"}],"container-title":["Cardiology in the Young"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1047951116002560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T23:22:35Z","timestamp":1555543355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1047951116002560\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,12]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S1047951116002560"],"URL":"https:\/\/doi.org\/10.1017\/s1047951116002560","relation":{},"ISSN":["1047-9511","1467-1107"],"issn-type":[{"value":"1047-9511","type":"print"},{"value":"1467-1107","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,12]]},"assertion":[{"value":"\u00a9 Cambridge University Press 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}