{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:30:53Z","timestamp":1676439053923},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"S5","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"unspecified","delay-in-days":58,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsc Microanal"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Alzheimer\u00b4s disease (AD) is characterized by extensive neuronal loss in brain areas related to memory and cognitive functions. Central to the neurodegenerative process is a peptide termed Abeta. The latter is the main component of senile plaques, one of the histopathological hallmarks of AD, and derives from proteolytic processing of the Alzheimer\u00b4s amyloid precursor protein (APP). Among the alterations induced by Abeta is increased cellular oxidative stress, imbalanced protein phosphorylation and cytoskeletal abnormalities, all factors that contribute to neuronal death.<\/jats:p>","DOI":"10.1017\/s1431927612012779","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T12:41:56Z","timestamp":1349008916000},"page":"23-24","source":"Crossref","is-referenced-by-count":2,"title":["Abeta Induces Abnormal Cytoskeletal Dynamics which are Reversible Upon Peptide Removal"],"prefix":"10.1093","volume":"18","author":[{"given":"A. G.","family":"Henriques","sequence":"first","affiliation":[]},{"given":"S. I.","family":"Vieira","sequence":"additional","affiliation":[]},{"given":"O. A. B. da Cruz e","family":"Silva","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2012,9,28]]},"container-title":["Microscopy and Microanalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1431927612012779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T21:01:22Z","timestamp":1676408482000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mam\/article\/18\/S5\/23\/6931890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":0,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1431927612012779"],"URL":"https:\/\/doi.org\/10.1017\/s1431927612012779","relation":{},"ISSN":["1431-9276","1435-8115"],"issn-type":[{"value":"1431-9276","type":"print"},{"value":"1435-8115","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}