{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:09:49Z","timestamp":1759961389450},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"S5","license":[{"start":{"date-parts":[[2012,9,28]],"date-time":"2012-09-28T00:00:00Z","timestamp":1348790400000},"content-version":"unspecified","delay-in-days":58,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microsc Microanal"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for painful disabling polyarthritis, undergoing re-emergence in the Indian Ocean and the Asian continent. Travelling and changing patterns of vector distribution, and abundance due to climate changes, make CHIKV a global threat without effective control strategies. One approach to reduce the CHIKV burden is the development of a vaccine. Virus-like particles (VLPs) are a safe and highly effective class of subunit vaccines that mimic the overall structure of virus particles. Accordingly, we aim to produce CHIKV VLPs in a baculovirus-insect cell system, well known for allowing high yields of recombinant protein expression, to be used as a vaccine preparation.<\/jats:p>","DOI":"10.1017\/s1431927612012950","type":"journal-article","created":{"date-parts":[[2012,9,30]],"date-time":"2012-09-30T12:41:56Z","timestamp":1349008916000},"page":"59-60","source":"Crossref","is-referenced-by-count":3,"title":["Expression of Chikungunya Virus-like Particles"],"prefix":"10.1093","volume":"18","author":[{"given":"R. A.","family":"Velez","sequence":"first","affiliation":[]},{"given":"A. P. Alves","family":"de Matos","sequence":"additional","affiliation":[]},{"given":"R.","family":"Parreira","sequence":"additional","affiliation":[]},{"given":"J. Piedade, B.","family":"Matos","sequence":"additional","affiliation":[]},{"given":"C.","family":"Correia","sequence":"additional","affiliation":[]},{"given":"A.","family":"Esteves","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2012,9,28]]},"container-title":["Microscopy and Microanalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1431927612012950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T21:01:28Z","timestamp":1676408488000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mam\/article\/18\/S5\/59\/6931909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":0,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1431927612012950"],"URL":"https:\/\/doi.org\/10.1017\/s1431927612012950","relation":{},"ISSN":["1431-9276","1435-8115"],"issn-type":[{"value":"1431-9276","type":"print"},{"value":"1435-8115","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}