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Consequently, their deterioration can have important detrimental consequences on the function and plasticity of neurons, and is thought to have a pivotal role in ageing and in the pathogenesis of several neurological disorders. Owing to their inherent physiological functions, mitochondria are subjected to particularly high levels of stress and have evolved specific molecular quality-control mechanisms to maintain the mitochondrial components. Here, we review some of the most recent advances in the understanding of mitochondrial stress-control pathways, with a particular focus on how defects in such pathways might contribute to neurodegenerative disease.<\/jats:p>","DOI":"10.1017\/s1462399410001456","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T06:33:23Z","timestamp":1271658803000},"source":"Crossref","is-referenced-by-count":72,"title":["Mitochondrial quality control and neurological disease: an emerging connection"],"prefix":"10.1017","volume":"12","author":[{"given":"In\u00eas Pimenta","family":"de Castro","sequence":"first","affiliation":[]},{"given":"L. 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