{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:30:09Z","timestamp":1764102609495,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":2869,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Animal"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1017\/s1751731112002030","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T11:19:05Z","timestamp":1353496745000},"page":"547-554","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of novel genes for bitter taste receptors in sheep (Ovis aries)"],"prefix":"10.1016","volume":"7","author":[{"given":"A.M.","family":"Ferreira","sequence":"first","affiliation":[]},{"given":"S.S.","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"E.","family":"Sales-Baptista","sequence":"additional","affiliation":[]},{"given":"A.M.","family":"Almeida","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1017\/S1751731112002030_bib001","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/10635150600755453","article-title":"Approximate likelihood ratio test for branches: a fast, accurate and powerful alternative","volume":"55","author":"Anisimova","year":"2006","journal-title":"Systematic Biology"},{"key":"10.1017\/S1751731112002030_bib002","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1146\/annurev.nutr.26.061505.111329","article-title":"Taste receptor genes","volume":"27","author":"Bachmanov","year":"2007","journal-title":"Annual Review of Nutrition"},{"key":"10.1017\/S1751731112002030_bib003","first-page":"203","article-title":"Mammalian bitter taste perception","volume":"47","author":"Behrens","year":"2009","journal-title":"Results and Problems in Cell Differentiation"},{"key":"10.1017\/S1751731112002030_bib004","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.physbeh.2011.02.010","article-title":"Gustatory and extragustatory functions of mammalian taste receptors","volume":"105","author":"Behrens","year":"2011","journal-title":"Physiology and Behavior"},{"key":"10.1017\/S1751731112002030_bib005","first-page":"93","article-title":"Abhandlung \u00fcber die Verteilung und Anordnung der Geschmackspapillen auf der Zunge der Hufthiere","volume":"10","author":"Brucher","year":"1884","journal-title":"Dtsche. Ztscht. f. Thiermed. u. vergl. Path."},{"key":"10.1017\/S1751731112002030_bib006","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/oxfordjournals.molbev.a026334","article-title":"Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis","volume":"17","author":"Castresana","year":"2000","journal-title":"Molecular Biology and Evolution"},{"key":"10.1017\/S1751731112002030_bib007","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature05401","article-title":"The receptors and cells for mammalian taste","volume":"444","author":"Chandrashekar","year":"2006","journal-title":"Nature"},{"key":"10.1017\/S1751731112002030_bib008","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/1471-2105-7-439","article-title":"TreeDyn: towards dynamic graphics and annotations for analyses of trees","volume":"7","author":"Chevenet","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1017\/S1751731112002030_bib009","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000068546","article-title":"Identification and characterization of human taste receptor genes belonging to the TAS2R family","volume":"98","author":"Conte","year":"2002","journal-title":"Cytogenetic and Genome Research"},{"key":"10.1017\/S1751731112002030_bib0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/physiolgenomics.00060.2003","article-title":"Evolutionary relationships of the Tas2r receptor gene families in mouse and human","volume":"14","author":"Conte","year":"2003","journal-title":"Physiological Genomics"},{"key":"10.1017\/S1751731112002030_bib0012","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2148-10-8","article-title":"BLAST-EXPLORER helps you building datasets for phylogenetic analysis","volume":"10","author":"Dereeper","year":"2010","journal-title":"BMC Evolutionary Biology"},{"key":"10.1017\/S1751731112002030_bib0011","doi-asserted-by":"crossref","first-page":"W465","DOI":"10.1093\/nar\/gkn180","article-title":"Phylogeny.fr: robust phylogenetic analysis for the non-specialist","volume":"6","author":"Dereeper","year":"2008","journal-title":"Nucleic Acids Research"},{"key":"10.1017\/S1751731112002030_bib0013","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2148-9-12","article-title":"Dynamic evolution of bitter taste receptor genes in vertebrates","volume":"9","author":"Dong","year":"2009","journal-title":"BMC Evolutionary Biology"},{"key":"10.1017\/S1751731112002030_bib0014","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Research"},{"key":"10.1017\/S1751731112002030_bib0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/omi.2008.0031","article-title":"Genetic variation in taste and its influence on food selection","volume":"13","author":"Garcia-Bailo","year":"2009","journal-title":"OMICS"},{"key":"10.1017\/S1751731112002030_bib0016","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1086\/378132","article-title":"Natural selection on the olfactory receptor gene family in humans and chimpanzees","volume":"73","author":"Gilad","year":"2003","journal-title":"American Journal of Human Genetics"},{"key":"10.1017\/S1751731112002030_bib0017","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/molbev\/msj106","article-title":"SMBE Tri-National Young Investigators. Proceedings of the SMBE Tri-National Young Investigators\u2019 Workshop 2005. Lineage-specific expansions and contractions of the bitter taste receptor gene repertoire in vertebrates","volume":"23","author":"Go","year":"2006","journal-title":"Molecular Biology and Evolution"},{"key":"10.1017\/S1751731112002030_bib0018","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/10635150390235520","article-title":"A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood","volume":"52","author":"Guindon","year":"2003","journal-title":"Systematic Biology"},{"key":"10.1017\/S1751731112002030_bib0019","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2052.2010.02100.x","article-title":"The sheep genome reference sequence: a work in progress","volume":"41","author":"Archibald","year":"2010","journal-title":"Animal Genetics"},{"key":"10.1017\/S1751731112002030_bib0020","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.1073\/pnas.1118360109","article-title":"Major taste loss in carnivorous mammals","volume":"109","author":"Jiang","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1017\/S1751731112002030_bib0021","doi-asserted-by":"crossref","first-page":"e1001258","DOI":"10.1371\/journal.pbio.1001258","article-title":"Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection","volume":"10","author":"Kijas","year":"2012","journal-title":"PLoS Biology"},{"key":"10.1017\/S1751731112002030_bib0022","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/humu.20203","article-title":"Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci","volume":"26","author":"Kim","year":"2005","journal-title":"Human Mutation"},{"key":"10.1017\/S1751731112002030_bib0023","first-page":"55","article-title":"Comparative morphological study on the tongue and lingual papillae of horses (Perissodactyla) and selected ruminantia (Artiodactyla)","volume":"110","author":"Kobayashi","year":"2005","journal-title":"Italian Journal of Anatomy and Embryology"},{"key":"10.1017\/S1751731112002030_bib0024","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"Journal of Molecular Biology"},{"key":"10.1017\/S1751731112002030_bib0026","series-title":"Goats: habitat, breeding and management","first-page":"93","article-title":"The Influence of oral environment on diet choices in goats: a focus on saliva protein composition","author":"Lamy","year":"2012"},{"key":"10.1017\/S1751731112002030_bib0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.physbeh.2009.07.002","article-title":"Sheep and goat saliva proteome analysis: a useful tool for ingestive behavior research?","volume":"98","author":"Lamy","year":"2009","journal-title":"Physiology and Behavior"},{"key":"10.1017\/S1751731112002030_bib0027","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/jmbi.2000.4042","article-title":"T-Coffee: a novel method for fast and accurate multiple sequence alignment","volume":"302","author":"Notredame","year":"2000","journal-title":"Journal of Molecular Biology"},{"key":"10.1017\/S1751731112002030_bib0028","doi-asserted-by":"crossref","first-page":"20421","DOI":"10.1073\/pnas.0709956104","article-title":"Genomic drift and copy number variation of sensory receptor genes in humans","volume":"104","author":"Nozawa","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1017\/S1751731112002030_bib0029","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/molbev\/msj028","article-title":"Contrasting modes of evolution between vertebrate sweet\/umami receptor genes and bitter receptor genes","volume":"23","author":"Shi","year":"2006","journal-title":"Molecular Biology and Evolution"},{"key":"10.1017\/S1751731112002030_bib0030","first-page":"175","article-title":"A hidden Markov model for predicting transmembrane helices in protein sequences","volume":"6","author":"Sonnhammer","year":"1998","journal-title":"Proceedings International Conference on Intelligent Systems for Molecular Biology"},{"key":"10.1017\/S1751731112002030_bib0031","unstructured":"Strachan T, Read AP 2004. Human molecular genetics. Garland Science, New York."},{"key":"10.1017\/S1751731112002030_bib0032","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/molbev\/msq279","article-title":"Diversification of Bitter Taste Receptor Gene Family in Western Chimpanzees","volume":"28","author":"Sugawara","year":"2011","journal-title":"Molecular Biology and Evolution"},{"key":"10.1017\/S1751731112002030_bib0033","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/bbrc.2001.5136","article-title":"Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting","volume":"285","author":"Ueda","year":"2001","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1017\/S1751731112002030_bib0034","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.nmd.2012.01.008","article-title":"Experimental validation of in silico predicted KCNA1, KCNA2, KCNA6 and KCNQ2 genes for association studies of peripheral nerve hyperexcitability syndrome in Jack Russell Terriers","volume":"22","author":"Van Poucke","year":"2012","journal-title":"Neuromuscular Disorders"},{"key":"10.1017\/S1751731112002030_bib0035","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1093\/hmg\/ddh289","article-title":"Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes","volume":"13","author":"Wang","year":"2004","journal-title":"Human Molecular Genetics"},{"key":"10.1017\/S1751731112002030_bib0036","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/10665270050081478","article-title":"A greedy algorithm for aligning DNA sequences","volume":"7","author":"Zhang","year":"2000","journal-title":"Journal of Computational Biology"},{"key":"10.1017\/S1751731112002030_bib0037","doi-asserted-by":"crossref","first-page":"420","DOI":"10.7150\/ijbs.3.420","article-title":"Candidate gene identification approach: progress and challenges","volume":"3","author":"Zhu","year":"2007","journal-title":"International Journal of Biological Sciences"}],"container-title":["Animal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731112002030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1751731112002030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1751731112002030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T23:15:52Z","timestamp":1761693352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1751731112002030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"alternative-id":["S1751731112002030"],"URL":"https:\/\/doi.org\/10.1017\/s1751731112002030","relation":{},"ISSN":["1751-7311"],"issn-type":[{"type":"print","value":"1751-7311"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel genes for bitter taste receptors in sheep (Ovis aries)","name":"articletitle","label":"Article Title"},{"value":"Animal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1017\/S1751731112002030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Animal Consortium. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}