{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:37:58Z","timestamp":1778056678213,"version":"3.51.4"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1611261, 61772566, and 81801132"],"award-info":[{"award-number":["U1611261, 61772566, and 81801132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2018YFC0910500"],"award-info":[{"award-number":["2018YFC0910500"]}]},{"name":"Introducing Innovative and Entrepreneurial Teams","award":["2016ZT06D211"],"award-info":[{"award-number":["2016ZT06D211"]}]},{"name":"Guangdong Frontier & Key Tech Innovation Program","award":["2018B010109006, 2019B020228001"],"award-info":[{"award-number":["2018B010109006, 2019B020228001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2020,4,27]]},"DOI":"10.1021\/acs.jcim.0c00064","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T22:59:17Z","timestamp":1585004357000},"page":"2388-2395","source":"Crossref","is-referenced-by-count":28,"title":["Accurately Predicting Mutation-Caused Stability Changes from Protein Sequences Using Extreme Gradient Boosting"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8821-0026","authenticated-orcid":true,"given":"Xuan","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory of High-Performance Computing, School of Computer Science, National University of Defense Technology, Changsha, Hunan 410073, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-2070","authenticated-orcid":true,"given":"Jianwen","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Data and Computer Science, Sun Yat-sen University, Guangzhou, Guangdong 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutong","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Data and Computer Science, Sun Yat-sen University, Guangzhou, Guangdong 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Data and Computer Science, Sun Yat-sen University, Guangzhou, Guangdong 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nong","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High-Performance Computing, School of Computer Science, National University of Defense Technology, Changsha, Hunan 410073, China"},{"name":"School of Data and Computer Science, Sun Yat-sen University, Guangzhou, Guangdong 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-2813","authenticated-orcid":true,"given":"Yuedong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Data and Computer Science, Sun Yat-sen University, Guangzhou, Guangdong 510275, China"},{"name":"Key Laboratory of Machine Intelligence and Advanced Computing, Sun Yat-sen University, Ministry of Education, Guangzhou, Guangdong 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1219240"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2009.08.003"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.07.012"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj103"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0109-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx439"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl190"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr576"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki387"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20810"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv291"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.01.012"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti1109"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm100"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth928"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00697"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw361"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21242"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki375"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1242"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","unstructured":"Chen, T.; Guestrin, C. Xgboost: A scalable tree boosting system. In  Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, San Francisco, August 2016; pp 785\u2013794.","DOI":"10.1145\/2939672.2939785"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1044"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4766-y"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0003-x"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1101\/610782"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty348"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty340"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz071"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046084"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.14.2994"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv665"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw678"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s008940100038"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/srep15479"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-S2-S6"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.25534"},{"key":"ref37\/cit37","first-page":"2825","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020251"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22921"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00442-4"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1110\/ps.0217002"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp445"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt691"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3027"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23838"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.0c00064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T01:54:17Z","timestamp":1682474057000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.0c00064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,23]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4,27]]}},"alternative-id":["10.1021\/acs.jcim.0c00064"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.0c00064","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,23]]}}}