{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T21:47:47Z","timestamp":1775598467945,"version":"3.50.1"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFA0502303"],"award-info":[{"award-number":["2016YFA0502303"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21633001"],"award-info":[{"award-number":["21633001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2020,9,28]]},"DOI":"10.1021\/acs.jcim.0c00074","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T22:29:09Z","timestamp":1589495349000},"page":"4350-4358","source":"Crossref","is-referenced-by-count":19,"title":["Discovery of Targeted Covalent Natural Products against PLK1 by Herb-Based Screening"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-3704","authenticated-orcid":true,"given":"Hao","family":"Liang","sequence":"first","affiliation":[{"name":"BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Liu","sequence":"additional","affiliation":[{"name":"BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Kuang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limin","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking-Tsinghua Center for Life Sciences at Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-2380","authenticated-orcid":true,"given":"Min","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8343-7587","authenticated-orcid":true,"given":"Luhua","family":"Lai","sequence":"additional","affiliation":[{"name":"BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"},{"name":"Peking-Tsinghua Center for Life Sciences at Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3410"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500469"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1582"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.492"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707875"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.01.009"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10111"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201408817"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2479"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b02008"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0917-9"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ci0003101"},{"key":"ref14\/cit14","unstructured":"Beijing Chuangteng Technology\nCo., Ltd. www.neotrident.com (accessed April 2020)."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00341"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/srep36767"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1039\/C8AN02482K"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.08.008"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ci500405g"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306430"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jm051256o"},{"key":"ref24\/cit24","unstructured":"Schr\u00f6dinger. www.schrodinger.com (accessed\nApril 2020)."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.11.018"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1063\/1.470043"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ci100350u"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00163"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky380"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112183"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00228"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ci9000053"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3184"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042689299"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/bi602474j"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0279-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2011.05.002"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00261"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.08.043"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600051"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12896"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13603"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1628"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2018.06.001"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/bi300531c"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.20.12606"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2016.02.079"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.6.3408"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3791\/50541"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X18500027"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0304-8"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/82_2018_121"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2018.05.011"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.6b00334"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00893"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/jm049353p"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1042\/bj1520023"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1055\/a-0731-0394"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.18-26"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/tx4001896"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv190"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00578"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403129200"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.01.006"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001270"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.01.047"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801745115"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.01.057"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.055"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12445"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.0c00074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:58:02Z","timestamp":1682510282000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.0c00074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,14]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9,28]]}},"alternative-id":["10.1021\/acs.jcim.0c00074"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.0c00074","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,14]]}}}