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The viral genome codes a cluster of proteins, each with a unique function in the event of host invasion or viral development. Under the current adverse situation, we employ virtual screening tools in searching for drugs and natural products which have been already deposited in DrugBank in an attempt to accelerate the drug discovery process. This study provides an initial evaluation of current drug candidates from various reports using our systemic in silico drug screening based on structures of viral proteins and human ACE2 receptor. Additionally, we have built an interactive online platform (https:\/\/shennongproject.ai\/) for browsing these results with the visual display of a small molecule docked on its potential target protein, without installing any specialized structural software. With continuous maintenance and incorporation of data from laboratory work, it may serve not only as the assessment tool for the new drug discovery but also an educational web site for the public.<\/jats:p>","DOI":"10.1021\/acs.jcim.0c00821","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T20:24:17Z","timestamp":1597177457000},"page":"5735-5745","source":"Crossref","is-referenced-by-count":36,"title":["Systemic\n                    <i>In Silico<\/i>\n                    Screening in Drug\nDiscovery for Coronavirus Disease (COVID-19) with an Online Interactive\nWeb Server"],"prefix":"10.1021","volume":"60","author":[{"given":"Chi","family":"Xu","sequence":"first","affiliation":[{"name":"Huawei Technologies Co., Ltd , , ,","place":["Shenzhen, China, 518100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunhui","family":"Ke","sequence":"additional","affiliation":[{"name":"Huazhong University of Science & Technology , , 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518100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huawei Technologies Co., Ltd , , ,","place":["Shenzhen, China, 518100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingning","family":"Wang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology , , ,","place":["Wuhan, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"He","sequence":"additional","affiliation":[{"name":"Huawei Technologies Co., Ltd , , ,","place":["Shenzhen, China, 518100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Huawei Technologies Co., Ltd , , ,","place":["Shenzhen, China, 518100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Li","sequence":"additional","affiliation":[{"name":"BioBank, The First Affiliated Hospital of Xi\u2019an Jiaotong University , ,","place":["Shaanxi, China, 710061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Yang","sequence":"additional","affiliation":[{"name":"BioBank, The First Affiliated Hospital of Xi\u2019an Jiaotong University , ,","place":["Shaanxi, China, 710061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Huang","sequence":"additional","affiliation":[{"name":"Huawei Technologies Co., Ltd , , ,","place":["Shenzhen, China, 518100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panjing","family":"Lv","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology , , ,","place":["Wuhan, China, 430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"BioBank, The First Affiliated Hospital of Xi\u2019an Jiaotong University , 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430030"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Huawei Technologies Co., Ltd , , ,","place":["Shenzhen, China, 518100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1670-6115","authenticated-orcid":true,"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"BioBank, The First Affiliated Hospital of Xi\u2019an Jiaotong University , ,","place":["Shaanxi, China, 710061"]},{"name":"Imperial College London , , ,","place":["London, U.K., SW7 2AZ"]},{"name":"Instrument Analysis Centre, of Xi\u2019an Jiaotong University , ,","place":["Shaanxi, China, 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