{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:27:07Z","timestamp":1782390427449,"version":"3.54.5"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004924","name":"Guangxi Traditional Chinese Medical University","doi-asserted-by":"publisher","award":["B170019"],"award-info":[{"award-number":["B170019"]}],"id":[{"id":"10.13039\/501100004924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81904198"],"award-info":[{"award-number":["81904198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010588","name":"Department of Environmental Protection of Guangdong Province","doi-asserted-by":"publisher","award":["2017B030314166"],"award-info":[{"award-number":["2017B030314166"]}],"id":[{"id":"10.13039\/501100010588","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2021,1,25]]},"DOI":"10.1021\/acs.jcim.0c00892","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T21:44:04Z","timestamp":1609364644000},"page":"252-262","source":"Crossref","is-referenced-by-count":10,"title":["(+\/\u2212)-Borneol Reverses Mitoxantrone Resistance against P-Glycoprotein"],"prefix":"10.1021","volume":"61","author":[{"given":"Rong","family":"Yang","sequence":"first","affiliation":[{"name":"Research Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuda","family":"Xie","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"Xie","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziren","family":"Su","sequence":"additional","affiliation":[{"name":"Mathematical Engineering Academy of Chinese Medicine, Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3654-2640","authenticated-orcid":true,"given":"Jiangyong","family":"Gu","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3599"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1730-1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01457"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.11069"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.09.012"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00429"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.08.022"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.03.007"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2018.1498560"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1172\/jci96817"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90595-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m114.552075"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2014.10.003"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/cr9000226"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204693"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m117.814186"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.ra119.012042"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206948"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m116.755884"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar7389"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00018"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21101356"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1080\/1061186x.2017.1339195"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.153551"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.4137\/dti.s12519"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2017.09.005"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22101730"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.12.025"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.2147\/ott.s174498"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201607300"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091446"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1159\/000487144"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161126051"},{"key":"ref34\/cit34","first-page":"4943","volume":"43","author":"Harker W. G.","year":"1983","journal-title":"Cancer Res."},{"key":"ref35\/cit35","first-page":"4091","volume":"45","author":"Harker W. G.","year":"1985","journal-title":"Cancer Res."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717044115"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7102"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.3"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.01.014"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2014.07.018"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/c6cp03670h"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/c7cp07623a"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq662"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10286"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153196"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.01.014"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168750"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.0c00892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:17:55Z","timestamp":1682468275000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.0c00892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,30]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,25]]}},"alternative-id":["10.1021\/acs.jcim.0c00892"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.0c00892","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,30]]}}}