{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:53:25Z","timestamp":1792029205201,"version":"4.4.0"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Forskningsr?det om H?lsa, Arbetsliv och V?lf?rd","doi-asserted-by":"publisher","award":["VR 2019-00608"],"award-info":[{"award-number":["VR 2019-00608"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030B-189363"],"award-info":[{"award-number":["310030B-189363"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F?rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSK-3_190825"],"award-info":[{"award-number":["CRSK-3_190825"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N6-methyladenosine (m6A) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with m6A-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the m6A-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.<\/jats:p>","DOI":"10.1021\/acs.jcim.0c01029","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T13:18:38Z","timestamp":1603113518000},"page":"5932-5935","source":"Crossref","is-referenced-by-count":73,"title":["Structural and Dynamic Insights into Redundant Function\nof YTHDF Proteins"],"prefix":"10.1021","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-2644","authenticated-orcid":true,"given":"Yaozong","family":"Li","sequence":"first","affiliation":[{"name":"University of Zurich , , ,","place":["Zurich, Switzerland, CH-8057"]},{"name":"Ume\u00e5 University , , ,","place":["Ume\u00e5, Sweden, SE-90187"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv K.","family":"Bedi","sequence":"additional","affiliation":[{"name":"University of Zurich , , ,","place":["Zurich, Switzerland, CH-8057"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-3481","authenticated-orcid":true,"given":"Elena V.","family":"Moroz-Omori","sequence":"additional","affiliation":[{"name":"University of Zurich , , ,","place":["Zurich, Switzerland, CH-8057"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-6792","authenticated-orcid":true,"given":"Amedeo","family":"Caflisch","sequence":"additional","affiliation":[{"name":"University of Zurich , , ,","place":["Zurich, Switzerland, CH-8057"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"2026081804412299300_cit1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1158\/2159-8290.CD-18-0959","article-title":"The Biology of m6A RNA Methylation\nin Normal and Malignant Hematopoiesis","volume":"9","author":"Vu","year":"2019","journal-title":"Cancer\nDiscovery"},{"key":"2026081804412299300_cit2","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.molmed.2018.07.010","article-title":"Epitranscriptomic Code and Its Alterations in Human\nDisease","volume":"24","author":"Kadumuri","year":"2018","journal-title":"Trends Mol. 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Genet."},{"key":"2026081804412299300_cit4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of\nthe Human and Mouse m6A RNA Methylomes Revealed by m6A-Seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"2026081804412299300_cit5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-Methyladenosine-Dependent Regulation of Messenger\nRNA Stability","volume":"505","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"2026081804412299300_cit6","doi-asserted-by":"publisher","first-page":"7004","DOI":"10.1021\/acs.jctc.9b00987","article-title":"Flexible Binding of m6A Reader Protein YTHDC1 to its\nPreferred RNA Motif","volume":"15","author":"Li","year":"2019","journal-title":"J. Chem. Theory Comput."},{"key":"2026081804412299300_cit7","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1021\/acschembio.9b00894","article-title":"Selectively\nDisrupting m6A-Dependent Protein-RNA Interactions with Fragments","volume":"15","author":"Bedi","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"2026081804412299300_cit8","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1101\/gad.301036.117","article-title":"m6A mRNA Modifications are Deposited in Nascent Pre-mRNA\nand are not Required for Splicing but do Specify Cytoplasmic Turnover","volume":"31","author":"Ke","year":"2017","journal-title":"Genes Dev."},{"key":"2026081804412299300_cit9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.tcb.2017.10.001","article-title":"Reading m6A in the Transcriptome:\nm6A-Binding Proteins","volume":"28","author":"Patil","year":"2018","journal-title":"Trends Cell Biol."},{"key":"2026081804412299300_cit10","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1016\/j.cell.2020.05.012","article-title":"A Unified Model\nfor the Function of YTHDF Proteins\nin Regulating m6A-Modified mRNA","volume":"181","author":"Zaccara","year":"2020","journal-title":"Cell"},{"key":"2026081804412299300_cit11","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.1021\/acs.analchem.8b05500","article-title":"A Reader-Based Assay for m6A Writers and Erasers","volume":"91","author":"Wiedmer","year":"2019","journal-title":"Anal. Chem."},{"key":"2026081804412299300_cit12","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 Facilitates\nTranslation and Decay of N6-Methyladenosine-Modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"2026081804412299300_cit13","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41586-018-0666-1","article-title":"m6A Facilitates Hippocampus-Dependent\nLearning and Memory Through YTHDF1","volume":"563","author":"Shi","year":"2018","journal-title":"Nature"},{"key":"2026081804412299300_cit14","doi-asserted-by":"publisher","first-page":"na","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 Destabilizes m6A-Containing\nRNA Through Direct Recruitment of the CCR4-NOT Deadenylase Complex","volume":"7","author":"Du","year":"2016","journal-title":"Nat. Commun."},{"key":"2026081804412299300_cit15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cell.2020.03.046","article-title":"G3BP1 is\na Tunable Switch that Triggers Phase Separation\nto Assemble Stress Granules","volume":"181","author":"Yang","year":"2020","journal-title":"Cell"},{"key":"2026081804412299300_cit16","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.1021\/acs.biochem.9b00485","article-title":"In Vitro\nSelection with a Site-Specifically\nModified RNA Library Reveals the Binding Preferences of N6-Methyladenosine\nReader Proteins","volume":"58","author":"Arguello","year":"2019","journal-title":"Biochemistry"},{"key":"2026081804412299300_cit17","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/s41422-019-0210-3","article-title":"Multivalent m6A Motifs\nPromote Phase Separation of YTHDF Proteins","volume":"29","author":"Gao","year":"2019","journal-title":"Cell Res."},{"key":"2026081804412299300_cit18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s13238-019-00660-2","article-title":"Binding to m6A RNA Promotes YTHDF2-Mediated Phase Separation","volume":"11","author":"Wang","year":"2020","journal-title":"Protein Cell"},{"key":"2026081804412299300_cit19","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41586-019-1374-1","article-title":"m6A Enhances the Phase Separation\nPotential of mRNA","volume":"571","author":"Ries","year":"2019","journal-title":"Nature"},{"key":"2026081804412299300_cit20","doi-asserted-by":"publisher","first-page":"24902","DOI":"10.1074\/jbc.M115.680389","article-title":"Structural\nBasis for the Discriminative Recognition of N6-Methyladenosine RNA\nby the Human YT521-B Homology Domain Family of Proteins","volume":"290","author":"Xu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2026081804412299300_cit21","doi-asserted-by":"publisher","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics\nof Nanosystems: Application to Microtubules and the Ribosome","volume":"98","author":"Baker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026081804412299300_cit22","doi-asserted-by":"publisher","first-page":"3453","DOI":"10.1039\/C7SC00055C","article-title":"Dynamic, Structural\nand Thermodynamic Basis of Insulin-Like Growth\nFactor 1 Kinase Allostery Mediated by Activation Loop Phosphorylation","volume":"8","author":"Li","year":"2017","journal-title":"Chem. Sci."}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.0c01029","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jcisd8\/article-pdf\/60\/12\/5932\/9624116\/ci0c01029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jcisd8\/article-pdf\/60\/12\/5932\/9624116\/ci0c01029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T09:39:12Z","timestamp":1787045952000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jcisd8\/article\/60\/12\/5932\/891346\/Structural-and-Dynamic-Insights-into-Redundant"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":22,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,10,19]]},"published-print":{"date-parts":[[2020,12,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.0c01029","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]}}}