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Despite its importance, there are relatively few studies on ring puckering and conformations, often focused on small cycloalkanes, 5- and 6-membered carbohydrate rings, and specific macrocycle families. We lack a general understanding of the puckering preferences of medium-sized rings and macrocycles. To address this, we provide an extensive conformational analysis of a diverse set of rings. We used Cremer\u2013Pople puckering coordinates to study the trends of the ring conformation across a set of 140\u202f000 diverse small molecules, including small rings, macrocycles, and cyclic peptides. By standardizing using key atoms, we show that the ring conformations can be classified into relatively few conformational clusters, based on their canonical forms. The number of such canonical clusters increases slowly with ring size. Ring puckering motions, especially pseudo-rotations, are generally restricted and differ between clusters. More importantly, we propose models to map puckering preferences to torsion space, which allows us to understand the inter-related changes in torsion angles during pseudo-rotation and other puckering motions. Beyond ring puckers, our models also explain the change in substituent orientation upon puckering. We also present a novel knowledge-based sampling method using the puckering preferences and coupled substituent motion to generate ring conformations efficiently. In summary, this work provides an improved understanding of general ring puckering preferences, which will in turn accelerate the identification of low-energy ring conformations for applications from polymeric materials to drug binding.<\/jats:p>","DOI":"10.1021\/acs.jcim.0c01144","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T14:56:57Z","timestamp":1612537017000},"page":"743-755","source":"Crossref","is-referenced-by-count":49,"title":["Understanding Ring Puckering in Small Molecules and\nCyclic Peptides"],"prefix":"10.1021","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1223-0431","authenticated-orcid":true,"given":"Lucian","family":"Chan","sequence":"first","affiliation":[{"name":"University of Oxford , , 24-29 St Giles\u2019 , ,","place":["Oxford, U.K., OX1 3LB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-1980","authenticated-orcid":true,"given":"Geoffrey R.","family":"Hutchison","sequence":"additional","affiliation":[{"name":"University of Pittsburgh , , 219 Parkman Avenue , , ,","place":["Pittsburgh, Pennsylvania, United States, 15260"]},{"name":"University of Pittsburgh , , , ,","place":["Pittsburgh, Pennsylvania, United States, 15260"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-8405","authenticated-orcid":true,"given":"Garrett M.","family":"Morris","sequence":"additional","affiliation":[{"name":"University of Oxford , , 24-29 St Giles\u2019 , ,","place":["Oxford, U.K., OX1 3LB"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"2026092806083723100_cit1","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1021\/ar2001765","article-title":"Conformational\nAnalyses of the Reaction\nCoordinate of Glycosidases","volume":"45","author":"Davies","year":"2012","journal-title":"Acc. 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