{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:38:48Z","timestamp":1772127528353,"version":"3.50.1"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2021,4,26]]},"DOI":"10.1021\/acs.jcim.0c01223","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T11:34:07Z","timestamp":1616499247000},"page":"2090-2098","source":"Crossref","is-referenced-by-count":1,"title":["Disentangling the Contribution of Each Descriptive Characteristic of Every Single Mutation to Its Functional Effects"],"prefix":"10.1021","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-3359","authenticated-orcid":true,"given":"C. K.","family":"Sruthi","sequence":"first","affiliation":[{"name":"Theoretical Sciences Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-4158","authenticated-orcid":true,"given":"Meher K.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Theoretical Sciences Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/35049558"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(01)05321-1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/bi00399a001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/science.2471267"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1492"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3027"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.175802"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20177908"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227621"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.11.003"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3769"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0138-4"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-16-s8-s1"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-020-3439-4"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20199380"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004290107"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.7554\/elife.32472"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.010"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0170-7"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.035"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","unstructured":"Ribeiro, M. T.; Singh, S.; Guestrin, C. \u201cWhy should i trust you?\u201d Explaining the predictions of any classifier.\n                      Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining\n                      , 2016; pp 1135\u20131144.","DOI":"10.1145\/2939672.2939778"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","unstructured":"Datta, A.; Sen, S.; Zick, Y. Algorithmic transparency via quantitative input influence: Theory and experiments with learning systems.\n                      2016 IEEE Symposium on Security and Privacy (SP)\n                      , 2016; pp 598\u2013617.","DOI":"10.1109\/SP.2016.42"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s10115-013-0679-x"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1009213726"},{"key":"ref25\/cit25","unstructured":"Lundberg, S.; Lee, S.I. A unified approach to interpreting model predictions, 2017. arXiv:1705.07874."},{"key":"ref26\/cit26","unstructured":"Lundberg, S. M.; Erion, G. G.; Lee, S.I. Consistent individualized feature attribution for tree ensembles, 2018. arXiv:1802.03888, arXiv preprint."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0304-0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.02.016"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2020.07.022"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007329"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-020-00314-0"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01101"},{"key":"ref33\/cit33","first-page":"307","volume-title":"Contributions to the Theory of Games","volume":"2","author":"Shapley L. S.","year":"1953"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614437114"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja0259640"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.117.300064"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422285112"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.5b00131"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030172"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10915"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(82)90515-0"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky995"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.038"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","unstructured":"Chen, T.; Guestrin, C. Xgboost: A scalable tree boosting system.\n                      Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining\n                      , 2016; pp 785\u2013794.","DOI":"10.1145\/2939672.2939785"},{"key":"ref48\/cit48","first-page":"2825","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku511"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.046"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.061"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","unstructured":"Luo, Y.; Vo, L.; Ding, H.; Su, Y.; Liu, Y.; Qian, W. W.; Zhao, H.; Peng, J. Evolutionary context-integrated deep sequence modeling for protein engineering, 2020. bioRxiv:10.1101\/2020.01.16.908509.","DOI":"10.1101\/2020.01.16.908509"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.0c01223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T04:35:40Z","timestamp":1682570140000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.0c01223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,26]]}},"alternative-id":["10.1021\/acs.jcim.0c01223"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.0c01223","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/867812","asserted-by":"object"}]},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}