{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:21:04Z","timestamp":1774426864524,"version":"3.50.1"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21673206"],"award-info":[{"award-number":["21673206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2021,10,25]]},"DOI":"10.1021\/acs.jcim.1c00825","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T11:38:48Z","timestamp":1634384328000},"page":"5203-5211","source":"Crossref","is-referenced-by-count":12,"title":["Hydrolysis Mechanism of the Linkers by Matrix Metalloproteinase-9 Using QM\/MM Calculations"],"prefix":"10.1021","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-0426","authenticated-orcid":true,"given":"Binbin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Chemistry, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengzhong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"En","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2392-9114","authenticated-orcid":true,"given":"Yingchun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2956-9781","authenticated-orcid":true,"given":"James W.","family":"Gauld","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of Windsor, Windsor N9B 3P4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-1401","authenticated-orcid":true,"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Zhejiang University, Hangzhou 310027, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.01.011"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1186\/ar401"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290308.x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2005.03.001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.18.8154"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01514"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2015.10.023"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019224"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2013.01.002"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"ref11\/cit11","first-page":"2396","volume":"7","author":"Schmalfeldt B.","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.015"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S129574"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201900329"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.02.014"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23020295"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303938200"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1039\/D0CB00114G"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.097"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408191101"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.08.008"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.082503"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-020-04339-w"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.08.002"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2018.1444510"},{"key":"ref26\/cit26","first-page":"1048","volume":"45","author":"Wang P.","year":"2010","journal-title":"Yao xue xue bao = Acta Pharm. Sin."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01278"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ja001461n"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jp803509h"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.mencom.2016.04.010"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s007750100295"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2015.02.079"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/ic0255656"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/cr500628b"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200802019"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21500"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2020.1853750"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600235"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu097"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ct1002626"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21123"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-1280(03)00285-9"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2614(89)85118-8"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1080\/08927020290018769"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/a909486e"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1039\/b508541a"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20065"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jp973084f"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1063\/1.463096"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/jp9028968"},{"key":"ref52\/cit52","volume-title":"Enzymatic Studies Using Quantum Mechanical and Molecular Mechanical Techniques[M]","author":"Faulder P. F.","year":"2001"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/ed058p32"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23977"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1039\/C7CP05572B"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b03966"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2019.1578694"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100900200"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/35036374"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.1c00825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T19:55:28Z","timestamp":1682538928000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.1c00825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,25]]}},"alternative-id":["10.1021\/acs.jcim.1c00825"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.1c00825","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}