{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:37:12Z","timestamp":1772127432480,"version":"3.50.1"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-001"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-009"},{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["OT2TR003441"],"award-info":[{"award-number":["OT2TR003441"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2021,12,27]]},"DOI":"10.1021\/acs.jcim.1c01285","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T09:35:21Z","timestamp":1637055321000},"page":"5734-5741","source":"Crossref","is-referenced-by-count":4,"title":["COVID-19 Knowledge Extractor (COKE): A Curated Repository of Drug\u2013Target Associations Extracted from the CORD-19 Corpus of Scientific Publications on COVID-19"],"prefix":"10.1021","volume":"61","author":[{"given":"Daniel","family":"Korn","sequence":"first","affiliation":[{"name":"Department of Computer Science, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"},{"name":"Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Pervitsky","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tesia","family":"Bobrowski","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6182-1748","authenticated-orcid":true,"given":"Vinicius M.","family":"Alves","sequence":"additional","affiliation":[{"name":"Office of Data Science, National Toxicology Program, NIEHS, Morrisville, North Carolina 27560, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Office of Data Science, National Toxicology Program, NIEHS, Morrisville, North Carolina 27560, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Bizon","sequence":"additional","affiliation":[{"name":"Renaissance Computing Institute, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Baker","sequence":"additional","affiliation":[{"name":"ParlezChem, 123 W. Union Street, Hillsborough, North Carolina 27278, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rada","family":"Chirkova","sequence":"additional","affiliation":[{"name":"Department of Computer Science, North Carolina State University, Raleigh, North Carolina 27606-5550, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artem","family":"Cherkasov","sequence":"additional","affiliation":[{"name":"Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-7036","authenticated-orcid":true,"given":"Eugene","family":"Muratov","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3802-8896","authenticated-orcid":true,"given":"Alexander","family":"Tropsha","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"ref1\/cit1","unstructured":"COVID-19 Map.\n                      Johns Hopkins Coronavirus Resource\nCenter\n                      . https:\/\/coronavirus.jhu.edu\/ (accessed Jun 21, 2021)."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.07.008"},{"key":"ref3\/cit3","unstructured":"Open-Access Data and Computational Resources\nto Address COVID-19.\n                      Office of Data Science\nStrategy, National Institutes of\nHealth\n                      . https:\/\/datascience.nih.gov\/covid-19-open-access-resources (accessed\nJun 26, 2020)."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3233\/DS-170001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa101"},{"key":"ref6\/cit6","unstructured":"SciBiteLabs\/CORD19: Annotated Data for the\nCOVID-19 Open Research\nDataset Challenge.\n                      GitHub\n                      . https:\/\/github.com\/SciBiteLabs\/CORD19 (accessed Jun 26, 2020)."},{"key":"ref7\/cit7","unstructured":"About us.\n                      SciBite\n                      . https:\/\/www.scibite.com\/# (accessed\nJun 26, 2020)."},{"key":"ref8\/cit8","unstructured":"Lu Wang, L.; Lo, K.; Chandrasekhar, Y.; Reas, R.; Yang, J.; Eide, D.; Funk, K.; Kinney, R.; Liu, Z.; Merrill, W.; Mooney, P.; Murdick, D.; Rishi, D.; Sheehan, J.; Shen, Z.; Stilson, B.; Wade, A. D.; Wang, K.; Wilhelm, C.; Xie, B.; Raymond, D.; Weld, D. S.; Etzioni, O.; Kohlmeier, S. CORD-19: The Covid-19 Open Research Dataset.\n                      arXiv Preprint\n                      .  \tarXiv:2004.10706, 2020."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj067"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-11-492"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0686-2"},{"key":"ref13\/cit13","unstructured":"OpenData, COVID-19.\n                      National\nCenter for Advancing\nTranslational Sciences\n                      . https:\/\/opendata.ncats.nih.gov\/covid19\/ (accessed Jun 26, 2020)."},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.f.230"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1881"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/ci100176x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.6b00129"},{"key":"ref18\/cit18","unstructured":"DataTables,\nTable plug-in for jQuery.\n                      DataTables\n                      . https:\/\/datatables.net\/ (accessed May 20, 2020)."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/minf.202000113"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0169-8"},{"key":"ref21\/cit21","unstructured":"Arbidol,\nOpenDataPortal.\n                      NCATS\n                      . https:\/\/opendata.ncats.nih.gov\/covid19\/databrowser?q=arbidol (accessed Jul 20, 2020)."},{"key":"ref22\/cit22","unstructured":"The Safety\n& Efficacy of Imatinib for the Treatment of SARS-COV-2\nInduced Pneumonia.\n                      U.S. National Library of\nMedicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04422678 (accessed Jun 26, 2020)."},{"key":"ref23\/cit23","unstructured":"Trial\nof Imatinib for Hospitalized Adults With COVID-19.\n                      U.S. National Library of Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04394416 (accessed Jun 26, 2020)."},{"key":"ref24\/cit24","unstructured":"Imatinib\nin COVID-19 Disease in Aged Patients (IMAGE-19).\n                      U.S. National Library of Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04357613 (accessed Jun 26, 2020)."},{"key":"ref25\/cit25","unstructured":"Pharmacokinetics,\nPharmacodynamics, and Safety Profile of Understudied\nDrugs Administered to Children per Standard of Care (POPS) (POPS or\nPOP02).\n                      U.S. National Library of Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04278404 (accessed Jun 26, 2020)."},{"key":"ref26\/cit26","unstructured":"Fluoxetine\nto Reduce Intubation and Death after COVID19 Infection.\n                      U.S. National Library of Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04377308 (accessed Jun 26, 2020)."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0444.1000287"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108518"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03977-14"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403596101"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.2174\/156802606776287090"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109985"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.14.150490"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.03.025"},{"key":"ref35\/cit35","unstructured":"U.S. Food and Drug Administration, Code\nof Federal Regulations 21. https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfcfr\/cfrsearch.cfm (accessed Jun 26, 2020)."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0282-0"},{"key":"ref37\/cit37","unstructured":"Trial to Evaluate the Efficacy and Safety\nof Nitazoxanide (NTZ) for\nPost-Exposure Prophylaxis of COVID-19 and Other Viral Respiratory\nIllnesses in Elderly Residents of Long-Term Care Facilities (LTCF).\n                      U.S. National Library of Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04343248 (accessed Jun 26, 2020)."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1101\/2020.07.01.183020"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.12.005"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1768151"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/v12060642"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25985"},{"key":"ref43\/cit43","unstructured":"Tetrandrine Tablets Used in the Treatment\nof COVID-19 (TT-NPC).\n                      U.S. National Library\nof Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04308317 (accessed Dec 13, 2020)."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03036-14"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2020.04.010"},{"key":"ref46\/cit46","unstructured":"Repurposing of Chlorpromazine in Covid-19\nTreatment (reCoVery).\n                      U.S. National Library\nof Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04366739 (accessed Jul 27, 2020)."},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1177\/2047487320919233"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0217OC"},{"key":"ref49\/cit49","unstructured":"Amiodarone or Verapamil in COVID-19 Hospitalized\nPatients With Symptoms\n(ReCOVery-SIRIO).\n                      U.S. National Library of\nMedicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04351763 (accessed Dec 10, 2020)."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2020.04.053"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","unstructured":"COVID-19 Information.\n                      DrugBank\n                      . https:\/\/www.drugbank.ca\/covid-19 (accessed Jun 26, 2020).","DOI":"10.4324\/9781003108924-3"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00052"},{"key":"ref53\/cit53","unstructured":"Niclosamide in Moderate COVID-19.\n                      U.S. National\nLibrary of Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04436458 (accessed Jul 27, 2020)."},{"key":"ref54\/cit54","unstructured":"Niclosamide\nfor Mild to Moderate COVID-19.\n                      U.S. National\nLibrary of Medicine\n                      . https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04399356 (accessed Jul 27, 2020)."},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.09.011"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38671-y"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.06.008"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/230117a0"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.04.026"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00683"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa718"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.1c01285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T01:05:30Z","timestamp":1682643930000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.1c01285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,16]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,27]]}},"alternative-id":["10.1021\/acs.jcim.1c01285"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.1c01285","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv.13289222.v1","asserted-by":"object"}]},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,16]]}}}