{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:31:45Z","timestamp":1772728305385,"version":"3.50.1"},"reference-count":89,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18OC0032608"],"award-info":[{"award-number":["NNF18OC0032608"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["7038-00199B"],"award-info":[{"award-number":["7038-00199B"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2022,12,26]]},"DOI":"10.1021\/acs.jcim.2c00635","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T12:53:41Z","timestamp":1661777621000},"page":"6788-6802","source":"Crossref","is-referenced-by-count":18,"title":["Lipid Modulation of a Class B GPCR: Elucidating the Modulatory Role of PI(4,5)P<sub>2<\/sub> Lipids"],"prefix":"10.1021","volume":"62","author":[{"given":"Lisbeth R.","family":"Kj\u00f8lbye","sequence":"first","affiliation":[{"name":"Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark"},{"name":"Novo Nordisk A\/S, Novo Nordisk Park 1, 2760 M\u00e5l\u00f8v, Denmark"}]},{"given":"Lars","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S, Novo Nordisk Park 1, 2760 M\u00e5l\u00f8v, Denmark"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S, Novo Nordisk Park 1, 2760 M\u00e5l\u00f8v, Denmark"}]},{"given":"Nils A.","family":"Berglund","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark"}]},{"given":"Jesper","family":"Ferkinghoff-Borg","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S, Novo Nordisk Park 1, 2760 M\u00e5l\u00f8v, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-5505","authenticated-orcid":true,"given":"Carol V.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, United Kingdom"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-1562","authenticated-orcid":true,"given":"Birgit","family":"Schi\u00f8tt","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark"},{"name":"Interdisciplinary Nanoscience Center, Aarhus University, Gustav Wieds vej 14, 8000 Aarhus C, Denmark"}]}],"member":"316","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-092115-025322"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0325-6"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2018.10.024"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.05.009"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.11.001"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.9.3.593"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221585110"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-7479-6"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094630"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nature22394"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz5346"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-021-00674-7"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.08.015"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.138"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(69)90540-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02534948"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.326"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39458-X"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81651-4"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21763"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/bi00848a019"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63595-1"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nature22363"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nature12393"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz5346"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1080"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.11.001"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1080"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1921851117"},{"issue":"4","key":"ref30\/cit30","first-page":"1263","volume":"17","author":"Jafari F.","year":"2018","journal-title":"Iran. J. Pharm. Res."},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00851"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.013793"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170104"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(64)90125-4"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2005.05.007"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4074"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(69)90421-4"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2015.09.018"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.530998"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/bi00839a056"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(87)90034-6"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(84)90255-4"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022775"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(75)90039-9"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a131126"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(75)90005-5"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.0c03368"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2016.27"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2017.10.017"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00451"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.03.008"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2013.11.009"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2017.05.005"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50766"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000289"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2015.08.028"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.01.023"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.06.009"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.0c00626"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/nature25153"},{"key":"ref62\/cit62","volume-title":"Schr\u00f6dinger Release 2017\u20134: Maestro","year":"2017"},{"key":"ref63\/cit63","unstructured":"MacroModel version 9.6, Prime, Version 2.1, QSite, version 5.0; Schr\u00f6dinger, LLC: New York, 2009."},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00264"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.46.9.1400"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20660"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00513"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00209"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/ct700324x"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/ct9002114"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000810"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2015.09.014"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2013.06.003"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23702"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1021\/jp003020w"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23354"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1063\/1.449071"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H"},{"key":"ref83\/cit83","unstructured":"Abraham, M. J.; van der Spoel, D.; Lindahl, E.; Hess, B. GROMACS User Manual, 2018."},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpc.2011.08.020"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.8b00143"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00708"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14424-8"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.73"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c00635","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c00635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T02:19:41Z","timestamp":1682475581000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.2c00635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":89,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2022,12,26]]}},"alternative-id":["10.1021\/acs.jcim.2c00635"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.2c00635","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]}}}