{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:24:18Z","timestamp":1750202658688,"version":"3.37.3"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100016109","name":"Taishan Industry Leading Talents","doi-asserted-by":"publisher","award":["2018TSCYCX-03"],"award-info":[{"award-number":["2018TSCYCX-03"]}],"id":[{"id":"10.13039\/501100016109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2022,11,28]]},"DOI":"10.1021\/acs.jcim.2c00978","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T07:53:30Z","timestamp":1667548410000},"page":"5780-5793","source":"Crossref","is-referenced-by-count":5,"title":["Stepwise Strategy to Identify Thrombin as a Hydrolytic Substrate for Nattokinase"],"prefix":"10.1021","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-7402","authenticated-orcid":true,"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang110016, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang110016, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yupeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang110016, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang110016, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-4056","authenticated-orcid":true,"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang110016, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-4256","authenticated-orcid":true,"given":"Fengjiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang110016, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271918785130"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062031"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.02.006"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-6135-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2174\/1871525716666171207153332"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101500"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-019-09860-8"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101751200"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030523"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.01.001"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.306853"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/35025229"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.10.009"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby077"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21117"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00864"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks493"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.1.221"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00610-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh131"},{"key":"ref22\/cit22","unstructured":"ACM\/IEEE SC 2005 Conference, IEEE Sc Conference; IEEE2006."},{"key":"ref23\/cit23","unstructured":"U.S. Department\nof Health and Human Services Food and Drug Administration: Branch, T. D. I.; 2002."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1208\/aapsj0901011"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40080976.x"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2018.09.004"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.12.140"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/cr000033x"},{"key":"ref29\/cit29","first-page":"101","volume-title":"Methods in Molecular Biology","volume":"1855","author":"Matsumoto H.","year":"2019"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114138"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/216857a0"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-882993"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939550"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050772"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c00978","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c00978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T10:34:51Z","timestamp":1682418891000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.2c00978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":34,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2022,11,28]]}},"alternative-id":["10.1021\/acs.jcim.2c00978"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.2c00978","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"type":"print","value":"1549-9596"},{"type":"electronic","value":"1549-960X"}],"subject":[],"published":{"date-parts":[[2022,11,4]]}}}