{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:05:19Z","timestamp":1773824719813,"version":"3.50.1"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100012540","name":"Guangdong Province Introduction of Innovative R&D Team","doi-asserted-by":"publisher","award":["2019B020213001"],"award-info":[{"award-number":["2019B020213001"]}],"id":[{"id":"10.13039\/100012540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["GJHZ20210705141803010"],"award-info":[{"award-number":["GJHZ20210705141803010"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20220531102205012"],"award-info":[{"award-number":["JCYJ20220531102205012"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21933010"],"award-info":[{"award-number":["21933010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22250710136"],"award-info":[{"award-number":["22250710136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62106253"],"award-info":[{"award-number":["62106253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017127","name":"Shenzhen Government","doi-asserted-by":"publisher","award":["JCYJ20200109114818703"],"award-info":[{"award-number":["JCYJ20200109114818703"]}],"id":[{"id":"10.13039\/100017127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017127","name":"Shenzhen Government","doi-asserted-by":"publisher","award":["KQTD20200820113106007"],"award-info":[{"award-number":["KQTD20200820113106007"]}],"id":[{"id":"10.13039\/100017127","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Funding for Innovation Project of Universities in Guangdong Province","award":["2018KTSCX192"],"award-info":[{"award-number":["2018KTSCX192"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2023,2,13]]},"DOI":"10.1021\/acs.jcim.2c01485","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T12:46:27Z","timestamp":1675255587000},"page":"835-845","source":"Crossref","is-referenced-by-count":56,"title":["Deep Learning-Based Bioactive Therapeutic Peptide Generation and Screening"],"prefix":"10.1021","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-1768","authenticated-orcid":true,"given":"Haiping","family":"Zhang","sequence":"first","affiliation":[{"name":"Shenzhen Institute of Synthetic Biology, Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China"}]},{"given":"Konda Mani","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Bharath Institute of Higher Education and Research, Chennai 600073, Tamil Nadu, India"}]},{"given":"Yanjie","family":"Wei","sequence":"additional","affiliation":[{"name":"Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[{"name":"Faculty of Computer Science and Control Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People\u2019s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, China"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[{"name":"Center for High Performance Computing, Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China"},{"name":"Faculty of Computer Science and Control Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"}]},{"given":"Xuli","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine, Shenzhen University, Shenzhen 518060, Guangdong, China"}]},{"given":"John Z. H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Institute of Synthetic Biology, Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China"},{"name":"East China Normal University, Shanghai 200062, China"},{"name":"NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai 200062, China"}]}],"member":"316","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1278"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00135-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.06.052"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102383"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps1801s69"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.4155\/tde.13.104"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00707"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21676"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.764225"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94873-3"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22203"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-016-0223-x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180629123117"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab160"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04156-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.725727"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-021-00310-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1101\/2022.01.27.478054"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c02088"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00442"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.805499"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/minf.201700111"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00205"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202104405"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.021"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr431"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024657"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.10.005"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25772-4"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00181"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/minf.201600011"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0053-0"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-020-0152-y"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab476"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s42254-020-0153-0"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008489"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.772296"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1162\/neco_a_01199"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914677117"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj040"},{"key":"ref41\/cit41","first-page":"2825","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127377"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb3405"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-803109-4.00010-6"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00467"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385885-6.00009-2"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1177\/2472555220942123"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25166-6"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(09)60003-7"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.182"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32381-3"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.12.006"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1101\/gad.315739.118"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180002"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1977"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.07.002"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1101\/2023.01.11.523536"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c01485","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c01485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T18:23:51Z","timestamp":1682533431000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.2c01485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,2,13]]}},"alternative-id":["10.1021\/acs.jcim.2c01485"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.2c01485","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.11.14.516530","asserted-by":"object"}]},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]}}}