{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T01:56:59Z","timestamp":1784253419246,"version":"3.55.0"},"reference-count":87,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2018\/31\/B\/NZ1\/04016"],"award-info":[{"award-number":["2018\/31\/B\/NZ1\/04016"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/35\/N\/NZ7\/04258"],"award-info":[{"award-number":["2019\/35\/N\/NZ7\/04258"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/01\/0\/NZ7\/00244"],"award-info":[{"award-number":["2020\/01\/0\/NZ7\/00244"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2023,2,13]]},"DOI":"10.1021\/acs.jcim.2c01503","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T18:13:26Z","timestamp":1674584006000},"page":"1012-1027","source":"Crossref","is-referenced-by-count":13,"title":["Identification of Novel CB2 Ligands through Virtual Screening and In Vitro Evaluation"],"prefix":"10.1021","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-5579","authenticated-orcid":true,"given":"Adam","family":"Stasiulewicz","sequence":"first","affiliation":[{"name":"Department of Drug Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland"},{"name":"Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lesniak","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Bujalska-Zadro\u017cny","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Pawi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2452-0724","authenticated-orcid":true,"given":"Joanna I.","family":"Sulkowska","sequence":"additional","affiliation":[{"name":"Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0374-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.08.005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082778"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1124\/mol.114.094649"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2016.1193157"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00406"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.12.011"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.06.010"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.206"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2018.11.016"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1995.tb20780.x"},{"key":"ref12\/cit12","first-page":"180","volume":"42","author":"Bridgeman M. B.","year":"2017","journal-title":"P T"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.204"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3257-1"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/432607"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2008.00109.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0384"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.003"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.06.066"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.145"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/med.21418"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.10.006"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2017.01.009"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/wmts.83"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2019.01.022"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2174\/187152710793361568"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00339"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.09.068"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.07.041"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.02.029"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1678738"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092690"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172628"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2300-4"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.prostaglandins.2018.09.004"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081919"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.05.023"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800997"},{"key":"ref39\/cit39","unstructured":"AbbVie,\nMARINOL (dronabinol)\n[drug label].  US Food and Drug Administration\nwebsite; https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/018651s029lbl.pdf. Revised August 2017. Accessed March 22, 2022."},{"key":"ref40\/cit40","unstructured":"Valeant Pharmaceuticals International,\nCesamet (nabilone) [drug label].  US\nFood and Drug Administration website; https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2006\/018677s011lbl.pdf. Revised May 2006. Accessed March 22, 2022."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.721765"},{"key":"ref42\/cit42","first-page":"763","volume":"77","author":"Werth V.","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/crocol\/otaa089"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706838"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13958"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.07.031"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.335273"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12850"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.712661"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.008"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.007"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/jm801044g"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23092183"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2004.10.002"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2018.11.013"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00696"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/ci049885e"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306430"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.11.034"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101301"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.06.010"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa971"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00559"},{"key":"ref64\/cit64","unstructured":"B IOVIA Discovery Studio v20.1.0.19295; BIOVIA,\nDassault Syst\u00e8mes: San Diego,\nCA, USA, 2020; https:\/\/www.3ds.com\/products-services\/biovia\/products\/molecular-modeling-simulation\/biovia-discovery-studio (accessed November 26, 2021)."},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540040211"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20945"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/ct300400x"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21367"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/2<236::AID-ANIE236>3.0.CO;2-M"},{"key":"ref72\/cit72","unstructured":"Schr\u00f6dinger Release 2017\u20131: Maestro; Schr\u00f6dinger, LLC, New York,\nNY, 2017; https:\/\/www.schrodinger.com\/products\/maestro (accessed November 26, 2021)."},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00864"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/jm030644s"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1002\/prot.23106"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1021\/jm020017n"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2016-0093"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv352"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1075"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00502"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.01.007"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b01101"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00466-3"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.2174\/0929867054020864"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/cr100098n"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2479"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c01503","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c01503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T22:25:10Z","timestamp":1682547910000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.2c01503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":87,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,2,13]]}},"alternative-id":["10.1021\/acs.jcim.2c01503"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.2c01503","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]}}}