{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:26:40Z","timestamp":1773329200953,"version":"3.50.1"},"reference-count":105,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100018538","name":"National Ten Thousand Talent Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","award":["2018QNA7023"],"award-info":[{"award-number":["2018QNA7023"]}],"id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872798"],"award-info":[{"award-number":["81872798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1909208"],"award-info":[{"award-number":["U1909208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LR21H300001"],"award-info":[{"award-number":["LR21H300001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\"Double Top-Class\" Universities","award":["181201*194232101"],"award-info":[{"award-number":["181201*194232101"]}]},{"name":"Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare"},{"name":"Westlake Laboratory (Westlake Laboratory of Life Science & Biomedicine)"},{"name":"Alibaba Cloud"},{"name":"Information Tech Center of Zhejiang University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2023,3,13]]},"DOI":"10.1021\/acs.jcim.2c01656","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T05:50:35Z","timestamp":1676872235000},"page":"1626-1636","source":"Crossref","is-referenced-by-count":16,"title":["MecDDI: Clarified Drug\u2013Drug Interaction Mechanism Facilitating Rational Drug Use and Potential Drug\u2013Drug Interaction Prediction"],"prefix":"10.1021","volume":"63","author":[{"given":"Wei","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-5392","authenticated-orcid":true,"given":"Yongchao","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"}]},{"given":"Xiuna","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"}]},{"given":"Huimin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"}]},{"given":"Shuiyang","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"}]},{"given":"Teng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"}]},{"given":"Yichao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"}]},{"given":"Qianqian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Affiliated Hangzhou First Peoples Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China"},{"name":"Clinical Pharmacy Research Center, Zhejiang University School of Medicine, Hangzhou 310009, China"}]},{"given":"Yunqing","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, The First Affiliated Hospital, Zhejiang University, Hangzhou 310000, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-0053","authenticated-orcid":true,"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 330110, China"}]},{"given":"Haibin","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Clinical Pharmacology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"Clinical Pharmacy Research Center, Zhejiang University School of Medicine, Hangzhou 310009, China"}]}],"member":"316","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.20846"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.06.012"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/s2352-3026(21)00232-5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02532-z"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27137-3"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c02194"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00801"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2221"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0255-3"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.10.001"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4461"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab089"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab582"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(18)30563-1"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocab019"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-00976-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14389"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00749-1"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01435"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01075"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1599"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-020-00879-x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-020-00867-1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00897"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02586-8"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz013"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01159-y"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06855-9"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-18-2839"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01096"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1990"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1336"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1622"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1434"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.817236"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15845"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-021-00640-7"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17018"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1743679"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-021-01131-y"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.723779"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1350"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac151"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab207"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac379"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-018-2562-7"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-021-00403-1"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab421"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab514"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab344"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab492"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac002"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105881"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab953"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1088"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1246"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa166"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab880"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1628003"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.7326\/m22-0281"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1007"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086499"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.608068"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13322"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.024"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-020-03074-w"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13152"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.674"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.2020.305782"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2874"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1662"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01516"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2021.08.016"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2018.1546841"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.923939"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1033"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1031"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1013"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa755"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0832-z"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.2174\/1389200221666200620210522"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07235-8"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.103969"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000456"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13741"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2019.01.006"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2018.1421172"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c01112"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010818-021511"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02244.x"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2212"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11020075"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.121.000401"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.10"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.01461"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2021.11.026"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-022-00639-0"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2017.04.021"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac597"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-022-04763-2"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac209"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa501"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803294115"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31370-9"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c01656","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.2c01656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T08:31:12Z","timestamp":1678696272000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.2c01656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,20]]},"references-count":105,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,3,13]]}},"alternative-id":["10.1021\/acs.jcim.2c01656"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.2c01656","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,20]]}}}