{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:31:27Z","timestamp":1781721087238,"version":"3.54.5"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":367,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","award":["OGI-196"],"award-info":[{"award-number":["OGI-196"]}],"id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010677","name":"H2020 Health","doi-asserted-by":"publisher","award":["875510"],"award-info":[{"award-number":["875510"]}],"id":[{"id":"10.13039\/100010677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2019-04416"],"award-info":[{"award-number":["RGPIN-2019-04416"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023921","name":"Structural Genomics Consortium","doi-asserted-by":"crossref","award":["1097737"],"award-info":[{"award-number":["1097737"]}],"id":[{"id":"10.13039\/501100023921","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EU\/EFPIA\/OICR\/McGill\/KTH\/Diamond Innovative Medicines Initiative 2 Joint Undertaking","award":["875510"],"award-info":[{"award-number":["875510"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2023,7,10]]},"DOI":"10.1021\/acs.jcim.3c00082","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T22:42:16Z","timestamp":1687560136000},"page":"4070-4078","source":"Crossref","is-referenced-by-count":29,"title":["Discovery of a Novel DCAF1 Ligand Using a Drug\u2013Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets"],"prefix":"10.1021","volume":"63","author":[{"given":"Serah W.","family":"Kimani","sequence":"first","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"},{"name":"Princess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Owen","sequence":"additional","affiliation":[{"name":"Recursion Pharmaceuticals Inc., Toronto, Ontario M5V 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-9683","authenticated-orcid":true,"given":"Stuart R.","family":"Green","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengling","family":"Li","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Li","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Dong","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-0367","authenticated-orcid":true,"given":"Peter J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-1839","authenticated-orcid":true,"given":"Suzanne","family":"Ackloo","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-6337","authenticated-orcid":true,"given":"David","family":"Kuter","sequence":"additional","affiliation":[{"name":"Recursion Pharmaceuticals Inc., Toronto, Ontario M5V 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Yang","sequence":"additional","affiliation":[{"name":"Recursion Pharmaceuticals Inc., Toronto, Ontario M5V 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"MacAskill","sequence":"additional","affiliation":[{"name":"Recursion Pharmaceuticals Inc., Toronto, Ontario M5V 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Scott","family":"MacKinnon","sequence":"additional","affiliation":[{"name":"Recursion Pharmaceuticals Inc., Toronto, Ontario M5V 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-3250","authenticated-orcid":true,"given":"Cheryl H.","family":"Arrowsmith","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"},{"name":"Princess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 2C4, Canada"},{"name":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-3309","authenticated-orcid":true,"given":"Matthieu","family":"Schapira","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Shahani","sequence":"additional","affiliation":[{"name":"Recursion Pharmaceuticals Inc., Toronto, Ontario M5V 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4361-3619","authenticated-orcid":true,"given":"Levon","family":"Halabelian","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM190404281501701"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1905.sp001128"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.302"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.179"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1490"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.130217"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1848"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nature05175"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.035"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-14-22"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.141230798"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-1119(00)00583-7"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001444"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjy085"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702102104"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10307"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08964"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02432-7"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116533"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-018-0285-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nature12815"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1052"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3791\/62510"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444906019949"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444996012255"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910045749"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909042073"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"ref33\/cit33","unstructured":"DeLano, W.; Schr\u00f6dinger, L. PyMOL. Retrieved Httpwwwpymolorgpymol."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(04)03069-7"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c02132"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1101\/2023.04.09.536153"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.1c00118"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.3c00082","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.3c00082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T11:10:40Z","timestamp":1719227440000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.3c00082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":37,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,7,10]]}},"alternative-id":["10.1021\/acs.jcim.3c00082"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.3c00082","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]}}}