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In this work, we extend this approach to constant-pressure (NPT) simulations. We reformulate the calculation of internal pressure from the density field by taking into account the intrinsic spread of the particles in space, which naturally leads to a direct anisotropy in the pressure tensor. The anisotropic contribution is crucial for reliably describing the physics of systems under pressure, as demonstrated by a series of tests on analytical and monatomic model systems as well as realistic water\/lipid biphasic systems. Using Bayesian optimization, we parametrize the field interactions of phospholipids to reproduce the structural properties of their lamellar phases, including area per lipid, and local density profiles. The resulting model excels in providing pressure profiles in qualitative agreement with all-atom modeling, and surface tension and area compressibility in quantitative agreement with experimental values, indicating the correct description of long-wavelength undulations in large membranes. Finally, we demonstrate that the model is capable of reproducing the formation of lipid droplets inside a lipid bilayer.<\/jats:p>","DOI":"10.1021\/acs.jcim.3c00186","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T14:41:55Z","timestamp":1680014515000},"page":"2207-2217","source":"Crossref","is-referenced-by-count":8,"title":["Soft Matter under\nPressure: Pushing Particle\u2013Field\nMolecular Dynamics to the Isobaric Ensemble"],"prefix":"10.1021","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1922-7796","authenticated-orcid":true,"given":"Samiran","family":"Sen","sequence":"first","affiliation":[{"name":"University of Oslo , , P.O. Box 1033 Blindern, ,","place":["Oslo, Norway, 0315"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-4876","authenticated-orcid":true,"given":"Morten","family":"Ledum","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. Box 1033 Blindern, ,","place":["Oslo, Norway, 0315"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-4885","authenticated-orcid":true,"given":"Sigbj\u00f8rn L\u00f8land","family":"Bore","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. Box 1033 Blindern, ,","place":["Oslo, Norway, 0315"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2266-5399","authenticated-orcid":true,"given":"Michele","family":"Cascella","sequence":"additional","affiliation":[{"name":"University of Oslo , , P.O. 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