{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:50:19Z","timestamp":1783716619479,"version":"3.55.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23PJD058"],"award-info":[{"award-number":["23PJD058"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2024,1,22]]},"DOI":"10.1021\/acs.jcim.3c01697","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T01:08:56Z","timestamp":1704244136000},"page":"340-347","source":"Crossref","is-referenced-by-count":33,"title":["ProSTAGE: Predicting Effects of Mutations on Protein Stability by Using Protein Embeddings and Graph Convolutional Networks"],"prefix":"10.1021","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-5547","authenticated-orcid":true,"given":"Gen","family":"Li","sequence":"first","affiliation":[{"name":"Production and R&D Center I of LSS, GenScript (Shanghai) Biotech Co., Ltd., Shanghai 200131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Yao","sequence":"additional","affiliation":[{"name":"Production and R&D Center I of LSS, GenScript (Shanghai) Biotech Co., Ltd., Shanghai 200131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8938-2225","authenticated-orcid":true,"given":"Long","family":"Fan","sequence":"additional","affiliation":[{"name":"Production and R&D Center I of LSS, GenScript (Shanghai) Biotech Co., Ltd., Shanghai 200131, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,1,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1903888116"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa074"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-062917-012102"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020606"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab555"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0607-466"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-022-00499-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0598-1"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2574"},{"key":"ref11\/cit11","first-page":"9689","volume":"32","author":"Rao R.","year":"2019","journal-title":"Proc. Adv. Neural Inf. Process. Syst."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2021.3095381"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw361"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12201-9"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa064"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1035"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa925"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa981"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw192"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008543"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060911"},{"key":"ref23\/cit23","author":"Wang M.","year":"2020","journal-title":"Deep Graph Library: A Graph-Centric, Highly-Performant Package for Graph Neural Networks"},{"key":"ref24\/cit24","unstructured":"Kipf, T. N.; Welling, M. Semi-Supervised Classification with Graph Convolutional Networks, 2017. arXiv:1609.02907. http:\/\/arxiv.org\/abs\/1609.02907 (accessed November 2023)."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-022-00457-9"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23303-9"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00799"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac325"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008291"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky300"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21511-x"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad472"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23876"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3027"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.3c01697","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.3c01697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T09:11:21Z","timestamp":1705914681000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.3c01697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,22]]}},"alternative-id":["10.1021\/acs.jcim.3c01697"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.3c01697","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,2]]}}}