{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:00:14Z","timestamp":1792033214618,"version":"4.4.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971180"],"award-info":[{"award-number":["31971180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271294"],"award-info":[{"award-number":["32271294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2024,4,22]]},"DOI":"10.1021\/acs.jcim.3c02011","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T16:51:15Z","timestamp":1712595075000},"page":"3548-3557","source":"Crossref","is-referenced-by-count":5,"title":["ESPDHot: An Effective Machine Learning-Based Approach for Predicting Protein\u2013DNA Interaction Hotspots"],"prefix":"10.1021","volume":"64","author":[{"given":"Lianci","family":"Tao","sequence":"first","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-073X","authenticated-orcid":true,"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangrui","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-3506","authenticated-orcid":true,"given":"Chunhua","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.3029"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14355"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17595"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-020-03675-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1126\/science.2471267"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz037"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty085"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinp.2021.103813"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.asoc.2021.108280"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11121808"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx236"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006615"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx698"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab567"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.75.051903"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/prot.25253"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa747"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/prot.23117"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac138"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad192"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.11.002"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160817933"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00513"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111471108"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-021-00348-5"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts620"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2005.159"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ct400387r"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1613\/jair.953"},{"key":"ref31\/cit31","first-page":"1322","volume-title":"2008 IEEE International Joint Conference on Neural Networks (IEEE World Congress on Computational Intelligence)","author":"He H.","year":"2008"},{"key":"ref32\/cit32","first-page":"878","volume-title":"2005 International Conference on Intelligent Computing","author":"Han H.","year":"2005"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/database\/bay034"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj103"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl158"},{"key":"ref36\/cit36","volume-title":"\u2019NACCESS\u2019 Computer Program","author":"Hubbard S. J.","year":"1993"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009284"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.374"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1234"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-553"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1109\/JSTSP.2008.923850"},{"key":"ref42\/cit42","volume-title":"Biochemistry","author":"Voet D.","year":"2011","edition":"4"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx218"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6807-8-21"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn222"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00146"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0278(97)00024-2"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902159106"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i11"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0390-z"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1206-1565"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1145\/2939672.2939785","volume-title":"Proceedings of the 22nd ACM SIGKdd International Conference on Knowledge Discovery and Data Mining","author":"Chen T.","year":"2016"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/BF02478259"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.682658"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1109\/34.574797"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-3702(97)00043-X"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/15.12.1039"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2019.107094"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1792-8"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2527-1"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2012.106"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-S1-S1"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.3c02011","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.3c02011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T08:12:11Z","timestamp":1713773531000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.3c02011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":64,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,4,22]]}},"alternative-id":["10.1021\/acs.jcim.3c02011"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.3c02011","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]}}}