{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T02:35:27Z","timestamp":1776220527334,"version":"3.50.1"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"17","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-153279"],"award-info":[{"award-number":["PJT-153279"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-166008"],"award-info":[{"award-number":["PJT-166008"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2024,9,9]]},"DOI":"10.1021\/acs.jcim.4c00711","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T10:11:20Z","timestamp":1724753480000},"page":"6745-6757","source":"Crossref","is-referenced-by-count":4,"title":["Antibody-SGM, a Score-Based Generative Model for Antibody Heavy-Chain Design"],"prefix":"10.1021","volume":"64","author":[{"given":"Xuezhi","family":"Xie","sequence":"first","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"},{"name":"Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4776-6017","authenticated-orcid":true,"given":"Pedro A.","family":"Valiente","sequence":"additional","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Sub","family":"Lee","sequence":"additional","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisun","family":"Kim","sequence":"additional","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3683-152X","authenticated-orcid":true,"given":"Philip M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada"},{"name":"Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3E1, Canada"},{"name":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"issue":"1","key":"ref1\/cit1","first-page":"60","volume":"10","author":"Litman G. W.","year":"1993","journal-title":"Mol. Biol. Evol."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010271"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2021.11.008"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2017.01.010"},{"key":"ref5\/cit5a","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa457"},{"key":"ref5\/cit5b","first-page":"024844","volume":"2020","author":"Tileli A.","year":"2020","journal-title":"bioRxiv"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1101\/2022.07.10.499510"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0598-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22732-w"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85274-7"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac016"},{"key":"ref11\/cit11","volume-title":"Advances in Neural Information Processing Systems","volume":"32","author":"Song Y.","year":"2019"},{"key":"ref12\/cit12","first-page":"arXiv:2011.1345","author":"Song Y.","year":"2020","journal-title":"arXiv preprint"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s43588-023-00440-3"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06415-8"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1101\/2023.05.08.539766"},{"key":"ref16\/cit16","volume-title":"NeurIPS 2022 Workshop on Learning Meaningful Representations of Life","author":"Vinod R.","year":"2022"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1914677117"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22658"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024109"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1043"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-021-00628-9"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad036"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c01488"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","unstructured":"Lin, G.; Milan, A.; Shen, C.; Reid, I. Refinenet: Multi-path refinement networks for high-resolution semantic segmentation. In  Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2017; pp 1925\u20131934.","DOI":"10.1109\/CVPR.2017.549"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00935"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90412-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.10.030"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.884132"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","unstructured":"Bujotzek, A.; Lipsmeier, F.; Harris, S. F.; Benz, J.; Kuglstatter, A.; Georges, G. In  Vh-vl orientation prediction for antibody humanization candidate selection: A case study, MAbs; Taylor & Francis, 2016; pp 288\u2013305.","DOI":"10.1080\/19420862.2015.1117720"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201493"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04927-7"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c00711","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c00711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T08:23:08Z","timestamp":1725870188000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.4c00711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":36,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,9,9]]}},"alternative-id":["10.1021\/acs.jcim.4c00711"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.4c00711","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,27]]}}}