{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T21:27:55Z","timestamp":1775942875509,"version":"3.50.1"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202201ZYTS424"],"award-info":[{"award-number":["YDZJ202201ZYTS424"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62102068"],"award-info":[{"award-number":["62102068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62231013"],"award-info":[{"award-number":["62231013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["JJKH20240826KJ"],"award-info":[{"award-number":["JJKH20240826KJ"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,2,10]]},"DOI":"10.1021\/acs.jcim.4c01528","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T03:50:21Z","timestamp":1737431421000},"page":"1615-1630","source":"Crossref","is-referenced-by-count":22,"title":["MMPD-DTA: Integrating Multi-Modal Deep Learning with Pocket-Drug Graphs for Drug-Target Binding Affinity Prediction"],"prefix":"10.1021","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-9285","authenticated-orcid":true,"given":"Guishen","family":"Wang","sequence":"first","affiliation":[{"name":"College of Computer Science and Engineering, Changchun University of Technology, North Yuanda Street No. 3000, Jilin 130012, China"}]},{"given":"Hangchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Computer Science and Engineering, Changchun University of Technology, North Yuanda Street No. 3000, Jilin 130012, China"}]},{"given":"Mengting","family":"Shao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Longmian Avenue No. 101, Jiangsu 211166, China"}]},{"given":"Shisen","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Computer Science and Engineering, Changchun University of Technology, North Yuanda Street No. 3000, Jilin 130012, China"}]},{"given":"Chen","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory for Bio-Electromagnetic Environment and Advanced Medical Theranostics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Longmian Avenue No. 101, Jiangsu 211166, China"}]}],"member":"316","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.02.019"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05905-z"},{"key":"ref3\/cit3","unstructured":"Zhang, Z.; Min, Y.; Zheng, S.; Liu, Q. In Molecule generation for target protein binding with structural motifs, The Eleventh International Conference on Learning Representations, 2023."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005690"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.future.2024.06.046"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.01.032"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c01027"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00976"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-022-04812-w"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae873"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2024.0476"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad056"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad008"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.051"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136151"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00072"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00417"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.2c01194"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.106145"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2022.09.006"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac526"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.2174\/1574893618666230912141426"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty593"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa544"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-23014-1"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","unstructured":"Zhao, Q.; Xiao, F.; Yang, M.; Li, Y.; Wang, J. In AttentionDTA: prediction of drug\u2013target binding affinity using attention model, 2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2019; pp 64\u201369.","DOI":"10.1109\/BIBM47256.2019.8983125"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1049\/cit2.12194"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad778"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2023.119658"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC05370E"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA02297G"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad340"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-024-01981-3"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084023"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC05180F"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa921"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","unstructured":"Mukherjee, S.; Ghosh, M.; Basuchowdhuri, P. In DeepGLSTM: deep graph convolutional network and LSTM based approach for predicting drug-target binding affinity, Proceedings of the 2022 SIAM International Conference on Data Mining (SDM), 2022; pp 729\u2013737.","DOI":"10.1137\/1.9781611977172.82"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00960"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107621"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2024.124647"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37477-x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00866"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00310"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac486"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00336"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030333"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab072"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad049"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2023.11.018"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbae081"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2023.05.005"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad718"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01830"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.2c03906"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","unstructured":"Zhang, Q.; Zhang, J.; Xu, Y.; Tao, D. In Vision transformer with quadrangle attention, IEEE Transactions on Pattern Analysis and Machine Intelligence, 2024.","DOI":"10.1109\/TPAMI.2023.3347693"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-024-00855-1"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49731-x"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad431"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad748"},{"key":"ref62\/cit62","unstructured":"Xu, K.; Hu, W.; Leskovec, J.; Jegelka, S. In How Powerful are Graph Neural Networks? International Conference on Learning Representations, 2018."},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-023-00756-9"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1706.03762"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2023.3275156"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1706.02216"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c01061"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00491"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00545"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.114"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty374"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b01997"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2308.09639"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28248005"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1609.02907"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2105.14491"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01528","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T09:12:35Z","timestamp":1739178755000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.4c01528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,2,10]]}},"alternative-id":["10.1021\/acs.jcim.4c01528"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.4c01528","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,20]]}}}