{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:59:49Z","timestamp":1773392389350,"version":"3.50.1"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62175037"],"award-info":[{"award-number":["62175037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,1,27]]},"DOI":"10.1021\/acs.jcim.4c01828","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T03:42:06Z","timestamp":1736307726000},"page":"981-996","source":"Crossref","is-referenced-by-count":6,"title":["MMSG-DTA: A Multimodal, Multiscale Model Based on Sequence and Graph Modalities for Drug-Target Affinity Prediction"],"prefix":"10.1021","volume":"65","author":[{"given":"Jiahao","family":"Xu","sequence":"first","affiliation":[{"name":"School of Information Engineering, Huzhou University, Huzhou 313000, China"},{"name":"Hangzhou Institute of Technology, Xidian University, Hangzhou 311231, China"}]},{"given":"Lei","family":"Ci","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Huzhou University, Huzhou 313000, China"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Huzhou University, Huzhou 313000, China"}]},{"given":"Guanhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Huzhou University, Huzhou 313000, China"},{"name":"Hangzhou Institute of Technology, Xidian University, Hangzhou 311231, China"}]},{"given":"Linhua","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Huzhou University, Huzhou 313000, China"},{"name":"Hangzhou Institute of Technology, Xidian University, Hangzhou 311231, China"}]},{"given":"Shixin","family":"Ye-Lehmann","sequence":"additional","affiliation":[{"name":"Hangzhou Institute of Technology, Xidian University, Hangzhou 311231, China"},{"name":"Faculty of Medicine, University Paris-Saclay, Paris 94276, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8162-0954","authenticated-orcid":true,"given":"Wei","family":"Long","sequence":"additional","affiliation":[{"name":"School of Information Engineering, Huzhou University, Huzhou 313000, China"}]}],"member":"316","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhealeco.2016.01.012"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00770"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3078"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1597"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.36.040306.132550"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.06.004"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.03.003"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby002"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2174\/157340911795677602"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.08.010"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-291"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2016.1144594"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbu010"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-017-0209-z"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty593"},{"key":"ref16\/cit16","unstructured":"\u00d6zt\u00fcrk, H.; Ozkirimli, E. \u00d6zg\u00fcr, A. Widedta: prediction of drug-target binding affinity,  arXiv preprint arXiv:1902.04166 https:\/\/arxiv.org\/abs\/1902.04166."},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa544"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA02297G"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa921"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC05180F"},{"key":"ref21\/cit21","first-page":"28877","volume":"34","author":"Ying C.","year":"2021","journal-title":"Advances in neural information processing systems"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-020-00456-1"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1109\/TNNLS.2020.2978386"},{"key":"ref24\/cit24","unstructured":"Vaswani, A. Attention is all you need.  Advances in Neural Information Processing Systems."},{"key":"ref25\/cit25","unstructured":"Hu, W.; Liu, B.; Gomes, J.; Zitnik, M.; Liang, P.; Pande, V.; Leskovec, J. Strategies for pre-training graph neural networks,  arXiv preprint. arXiv:1905.12265 https:\/\/arxiv.org\/abs\/1905.12265."},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2574"},{"key":"ref27\/cit27","unstructured":"Veli\u010dkovi\u0107, P.; Cucurull, G.; Casanova, A.; Romero, A.; Lio, P.; Bengio, Y. Graph attention networks.  arXiv preprint. arXiv:1710.10903 https:\/\/arxiv.org\/abs\/1710.10903."},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1990"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ci400709d"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.530"},{"key":"ref31\/cit31","first-page":"14501","volume":"35","author":"Ramp\u00e1\u0161ek L.","year":"2022","journal-title":"Advances in Neural Information Processing Systems"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107621"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2023.11.018"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-024-05671-3"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2023.108003"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105126"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2024.124647"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.1c00867"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107512"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC00148K"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1049\/cit2.12194"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad355"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad976"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-10390-0"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c01504"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1101\/2024.07.17.603955"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01828","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:15:26Z","timestamp":1737969326000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.4c01828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,7]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,27]]}},"alternative-id":["10.1021\/acs.jcim.4c01828"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.4c01828","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,7]]}}}