{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:09:31Z","timestamp":1774534171237,"version":"3.50.1"},"reference-count":79,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2023J078"],"award-info":[{"award-number":["2023J078"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022955","name":"Fundamental Research Funds for the Provincial Universities of Zhejiang","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11904189"],"award-info":[{"award-number":["11904189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM121342"],"award-info":[{"award-number":["P20GM121342"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM145409"],"award-info":[{"award-number":["R35GM145409"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM121342"],"award-info":[{"award-number":["P20GM121342"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM145409"],"award-info":[{"award-number":["R35GM145409"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South Carolina Alzheimer?s Disease Research Center"},{"name":"Lihuili Hospital","award":["2023BSKY-HFJ"],"award-info":[{"award-number":["2023BSKY-HFJ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2024,11,25]]},"DOI":"10.1021\/acs.jcim.4c01839","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T16:23:11Z","timestamp":1730910191000},"page":"8616-8627","source":"Crossref","is-referenced-by-count":10,"title":["Exploring the Impact of Physiological C-Terminal Truncation on \u03b1-Synuclein Conformations to Unveil Mechanisms Regulating Pathological Aggregation"],"prefix":"10.1021","volume":"64","author":[{"given":"Fengjuan","family":"Huang","sequence":"first","affiliation":[{"name":"Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated Lihuili Hospital of Ningbo University, Ningbo 315211, China"}]},{"given":"Jiajia","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"}]},{"given":"Huan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"}]},{"given":"Xiaohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-5869","authenticated-orcid":true,"given":"Yu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Sport and Exercise Science, Zhejiang University, Hangzhou 310058, China"}]},{"given":"Jiangfang","family":"Lian","sequence":"additional","affiliation":[{"name":"Ningbo Institute of Innovation for Combined Medicine and Engineering (NIIME), The Affiliated Lihuili Hospital of Ningbo University, Ningbo 315211, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-6336","authenticated-orcid":true,"given":"Feng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-7131","authenticated-orcid":true,"given":"Yunxiang","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology, Ningbo University, Ningbo 315211, China"},{"name":"Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States"}]}],"member":"316","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3810"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00647-2"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00372B"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01122"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0060-8"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.09.001"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2825"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3194"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101125"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315346111"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21937-3"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.04.004"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP04138G"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02696-z"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.235013"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2015.1033016"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00531"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nature15368"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2018.11.005"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.14361"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.05.066"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/bi020429y"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0384-x"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202308753"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008919200"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16564-3"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005603"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.001862"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610099113"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.10.003"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.10.042"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV120.011743"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C8SC01109E"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315006121"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh3457"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32687-1"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR02407G"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411805200"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3433"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105736"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.101978"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/jp2114576"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.03.013"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0607-466"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ci8001167"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.2741\/3039"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22479"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0134(19990501)35:2<133::AID-PROT1>3.0.CO;2-N"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1039\/D2CP02851D"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c01202"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202202642"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(06)12019-4"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/iub.223"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00414"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c01566"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.10.103"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c01470"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/2<236::AID-ANIE236>3.0.CO;2-M"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4538"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00694"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2022.167713"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712179105"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2022.167859"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.598607"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/pro.630"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2024.09.019"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP04697D"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.7554\/elife.36402"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2022.11.013"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00859"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad526"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.3c02633"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00462-7"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54063-8"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00533"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201309001"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102678"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109120"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01839","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T09:11:07Z","timestamp":1732525867000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.4c01839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":79,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11,25]]}},"alternative-id":["10.1021\/acs.jcim.4c01839"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.4c01839","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,6]]}}}