{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T02:00:20Z","timestamp":1769047220041,"version":"3.49.0"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,1,27]]},"DOI":"10.1021\/acs.jcim.4c01928","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:34:41Z","timestamp":1736350481000},"page":"517-527","source":"Crossref","is-referenced-by-count":1,"title":["Engineering Protein Dynamics through Mutational Energy Landscape Traps"],"prefix":"10.1021","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6575-1687","authenticated-orcid":true,"given":"Lucas de Almeida","family":"Machado","sequence":"first","affiliation":[{"name":"Instituto Nacional de Sa\u00fade da Mulher, da Crian\u00e7a e do Adolescente \u2212 Fiocruz, Rio de Janeiro, Brazil 22250-020"},{"name":"Laborat\u00f3rio de Gen\u00f4mica Aplicada e Bioinova\u00e7\u00f5es \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"}]},{"given":"Jo\u00e3o","family":"Sartori","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Aplicada e Bioinova\u00e7\u00f5es \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Computacional e Sistemas \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"}]},{"given":"Paula Fernandes da Costa","family":"Franklin","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Aplicada e Bioinova\u00e7\u00f5es \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Computacional e Sistemas \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-286X","authenticated-orcid":true,"given":"Mauricio G. S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Programa de Computa\u00e7\u00e3o Cient\u00edfica \u2212 Fiocruz, Rio de Janeiro, Brazil 21040-900"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Computacional e Sistemas \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-543X","authenticated-orcid":true,"given":"Ana Carolina Ramos","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Aplicada e Bioinova\u00e7\u00f5es \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Computacional e Sistemas \u2212 Instituto Oswaldo Cruz\/Fiocruz, Rio de Janeiro, Brazil 21040-900"}]}],"member":"316","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7366-8_1"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06415-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32007-7"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/bi301559q"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.961"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1689"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1201\/9781420035070"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.76"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.093008.131258"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1063\/1.4816375"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22855"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.15.4995"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00003"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709915104"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19560-9"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/srep41212"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00571"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bej.2015.03.011"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2020.03.020"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00109"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/bi4007513"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0478-5"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0479-4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0483-8"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1107\/S0108768189009195"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.4236\/ajps.2017.87116"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl461"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.6b01991"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/262325a0"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq007"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/bi902153g"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.7b00125"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi0506s15"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab377"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20291"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22711"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts310"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab176"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01928","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c01928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T09:15:21Z","timestamp":1737969321000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.4c01928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,27]]}},"alternative-id":["10.1021\/acs.jcim.4c01928"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.4c01928","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}