{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:19:23Z","timestamp":1769829563876,"version":"3.49.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["21ZR1400400"],"award-info":[{"award-number":["21ZR1400400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172088"],"award-info":[{"award-number":["62172088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62272290"],"award-info":[{"award-number":["62272290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,3,24]]},"DOI":"10.1021\/acs.jcim.4c02424","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T11:43:22Z","timestamp":1741779802000},"page":"3090-3103","source":"Crossref","is-referenced-by-count":2,"title":["Multidependency Graph Convolutional Networks and Contrastive Learning for Drug Repositioning"],"prefix":"10.1021","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5931-9006","authenticated-orcid":true,"given":"Yanglan","family":"Gan","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology","place":["Shanghai, China"]},{"name":"Donghua University","place":["Shanghai, China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4290-1808","authenticated-orcid":true,"given":"Shengnan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology","place":["Shanghai, China"]},{"name":"Donghua University","place":["Shanghai, China"]}]},{"given":"Guangwei","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology","place":["Shanghai, China"]},{"name":"Donghua University","place":["Shanghai, China"]}]},{"given":"Cairong","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology","place":["Shanghai, China"]},{"name":"Donghua University","place":["Shanghai, China"]}]},{"given":"Guobing","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Computer Engineering and Science","place":["Shanghai, China"]},{"name":"Shanghai University","place":["Shanghai, China"]}]}],"member":"316","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbz176"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-60756-6"},{"key":"ref3\/cit3","first-page":"1","volume-title":"Drug Repurposing: Innovative Approaches to Drug Discovery and Development","author":"Katukam L. P.","year":"2024"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","unstructured":"Dabhade, P.; Bharadwaj, A.; Bagde, A.; Shende, P. Computational drug designing and drug discovery approach in drug repositioning: A review. In  AIP Conference Proceedings; AIP Publishing, 2024.","DOI":"10.1063\/5.0240411"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbae172"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2021.1883585"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","unstructured":"Tiwari, S. W.; Joshi, M.; Chand, G.; Gwasikoti, J.; Mittal, A.; Sharma, P. K. In  Transforming Pharmacological Research: Utilizing AI and Machine Learning in Drug Discovery and Development, 2024 2nd International Conference on Self Sustainable Artificial Intelligence Systems (ICSSAS); IEEE, 2024; pp 75\u201378.","DOI":"10.1109\/ICSSAS64001.2024.10760304"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-5-30"},{"key":"ref9\/cit9","unstructured":"Ghorbanali, Z.; Zare Mirakabad, F.; Mohammadpour, B. DRP-VEM: Drug Repositioning Using Voting Ensemble Model AUT J. Math. Comput. 2024."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa062"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz331"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c01589"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz418"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.knosys.2023.111329"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2023.3272154"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00573"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab581"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab319"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad748"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","unstructured":"Schlichtkrull, M.; Kipf, T. N.; Bloem, P.; Van\nDen Berg, R.; Titov, I.; Welling, M. In  Modeling Relational Data with Graph Convolutional Networks, The Semantic Web (ESWC 2018; Springer, 2018; pp 593\u2013607.","DOI":"10.1007\/978-3-319-93417-4_38"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1109\/TNNLS.2024.3371592"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2023.109874"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1109\/TKDE.2024.3389966"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1109\/jbhi.2024.3372527"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2024.109653"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","unstructured":"Li, Q.; Han, Z.; Wu, X.M. Deeper insights into graph convolutional networks for semi-supervised learning Proc. the AAAI Conf. Artif. Int. 2018; Vol. 32 10.1609\/aaai.v32i1.11604.","DOI":"10.1609\/aaai.v32i1.11604"},{"key":"ref27\/cit27","unstructured":"Glorot, X.; Bengio, Y. In  Understanding the Difficulty of Training Deep Feedforward Neural Networks, Proceedings of the Thirteenth International Conference on Artificial Intelligence and Statistics PMLR; 2010; pp 249\u2013256."},{"key":"ref28\/cit28","unstructured":"Dauphin, Y. N.; Fan, A.; Auli, M.; Grangier, D. In  Language modeling with gated convolutional networks, Proceedings of the 34th International Conference on Machine Learning; PLMR, 2017; pp 933\u2013941."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","unstructured":"He, X.; Deng, K.; Wang, X.; Li, Y.; Zhang, Y.; Wang, M. In  LightGCN: Simplifying and Powering Graph Convolution Network for Recommendation, SIGIR \u201820: Proceedings of the 43rd International ACM SIGIR Conference on Research and Development in Information Retrieval; ACM, 2020; pp 639\u2013648.","DOI":"10.1145\/3397271.3401063"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","unstructured":"Hu, Z.; Dong, Y.; Wang, K.; Sun, Y. In  Heterogeneous Graph Transformer, Proceedings of The Web Conference;l ACM, 2020; pp 2704\u20132710.","DOI":"10.1145\/3366423.3380027"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1109\/TKDE.2023.3288135"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","unstructured":"Yu, J.; Yin, H.; Li, J.; Wang, Q.; Hung, N. Q. V.; Zhang, X. In  Self-Supervised Multi-Channel Hypergraph Convolutional Network for Social Recommendation, Proceedings of the Web Conference; ACM, 2021; pp 413\u2013424.","DOI":"10.1145\/3442381.3449844"},{"key":"ref33\/cit33","unstructured":"Tian, Y.; Sun, C.; Poole, B.; Krishnan, D.; Schmid, C.; Isola, P. In  What Makes for Good Views for Contrastive Learning?, Advances in Neural Information Processing Systems 33 (NeurIPS 2020); NeurIPS, 2020; pp 6827\u20136839."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","unstructured":"Lin, Z.; Tian, C.; Hou, Y.; Zhao, W. X. In  Improving Graph Collaborative Filtering with Neighborhood-Enriched Contrastive Learning, Proceedings of the ACM Web Conference; ACM, 2022; pp 2320\u20132329.","DOI":"10.1145\/3485447.3512104"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.26"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw228"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw770"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa243"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki033"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj067"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa891"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2021.3082466"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","unstructured":"Davis, J.; Goadrich, M. In  The relationship between Precision-Recall and ROC Curves, Proceedings of the 23rd International Conference on Machine Learning; ACM, 2006; pp 233\u2013240.","DOI":"10.1145\/1143844.1143874"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118432"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008040"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","unstructured":"Xia, L.; Huang, C.; Xu, Y.; Zhao, J.; Yin, D.; Huang, J. In  Hypergraph Contrastive Collaborative Filtering, Proceedings of the 45th International ACM SIGIR conference on research and development in information retrieval; ACM, 2022; pp 70\u201379.","DOI":"10.1145\/3477495.3532058"},{"key":"ref47\/cit47","unstructured":"Mao, C.; Yao, L.; Luo, Y. MedGCN: Graph convolutional networks for multiple medical tasks 2019. arXiv:1904.00326. arXiv.org e-Print archive. https:\/\/arxiv.org\/abs\/1904.00326."},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2023.119982"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1109\/TNNLS.2024.3519427"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-016-0336-5"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","unstructured":"Galli, S.; De Carolis, L.; Bianchini, E.; Alborghetti, M.; Cali\u00f2, B.; Pacilio, P.; Fanciulli, A.; Pontieri, F. E.; Rinaldi, D.Effects of levodopa\/carbidopa intestinal gel infusion on autonomic symptoms in advanced Parkinson\u2019s disease: a systematic review Clin. Auton. Res. 2024 10.1007\/s10286-024-01090-9.","DOI":"10.1007\/s10286-024-01090-9"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1177\/0269216310381662"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3458.2003.tb00254.x"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200016030-00005"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/life13051095"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.93"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c02424","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.4c02424","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T19:31:14Z","timestamp":1742844674000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.4c02424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,3,24]]}},"alternative-id":["10.1021\/acs.jcim.4c02424"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.4c02424","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]}}}