{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:10:25Z","timestamp":1768014625459,"version":"3.49.0"},"reference-count":42,"publisher":"American Chemical Society (ACS)","issue":"7","funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["103-2325-B-400-005"],"award-info":[{"award-number":["103-2325-B-400-005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2015,7,27]]},"DOI":"10.1021\/acs.jcim.5b00130","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T01:51:18Z","timestamp":1435197078000},"page":"1426-1434","source":"Crossref","is-referenced-by-count":36,"title":["Rule-Based Prediction Models of Cytochrome P450 Inhibition"],"prefix":"10.1021","volume":"55","author":[{"given":"Bo-Han","family":"Su","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"}]},{"given":"Yi-shu","family":"Tu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"}]},{"given":"Chieh","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"}]},{"given":"Chi-Yu","family":"Shao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"}]},{"given":"Olivia A.","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"}]},{"given":"Yufeng J.","family":"Tseng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Electronics\rand Bioinformatics and \u00a7Department of Computer\rScience and Information Engineering, National Taiwan University, No.\r1 Sec. 4, Roosevelt Road, Taipei, Taiwan 106"}]}],"member":"316","published-online":{"date-parts":[[2015,7,2]]},"reference":[{"issue":"3","key":"ref1\/cit1","first-page":"391","volume":"76","author":"Lynch T.","year":"2007","journal-title":"Am. Fam. Physician"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032424"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.4065\/84.7.613"},{"key":"ref4\/cit4","volume-title":"Current diagnosis & treatment in gastroenterology","author":"Friedman E. S.","year":"2003"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2012.2541"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/mp900217x"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/ci200028n"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/jm060267u"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/jm060333s"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/ci200091h"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ci900299a"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-10-8"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt325"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/ci200311w"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ci4000536"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17089283"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903158940"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/14756360600952183"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-120001391"},{"issue":"7","key":"ref20\/cit20","first-page":"936","volume":"29","author":"Ekins S.","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-008-9225-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-007-9139-6"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.4.8.1053"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv043"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1581"},{"key":"ref26\/cit26","unstructured":"NIH Chemical Genomics Center PubChem Assay ID 1851: Cytochrome panel assay with activity outcomes.https:\/\/pubchem.ncbi.nlm.nih.gov\/assay\/assay.cgi?aid=1851(accessed May 10, 2014)."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21707"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/ci00028a014"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ci990307l"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ci0342066"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/BF02311772"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/ci980339t"},{"key":"ref33\/cit33","unstructured":"Laggner, C.SMARTS Patterns for Functional Group Classification.http:\/\/code.google.com\/p\/semanticchemistry\/source\/browse\/wiki\/ (2013) ."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ci800038f"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/194178b0"},{"key":"ref36\/cit36","unstructured":"Talete Dragon.http:\/\/www.talete.mi.it\/products\/dragon_description.htm(accessed July 15, 2015)."},{"key":"ref37\/cit37","unstructured":"Haney, D. N.; Hall, L. H.; Molconn-Z.http:\/\/www.edusoft-lc.com\/molconn\/mconpubs.html(accessed July 15, 2015)."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1145\/584091.584093"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-012-9595-5"},{"key":"ref40\/cit40","volume-title":"C4.5: Programs for Machine Learning","author":"Quinlan J. R.","year":"1993"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2440-0","volume-title":"The Nature of Statistical Learning Theory","author":"Vapnik V. N.","year":"1995"},{"key":"ref42\/cit42","volume-title":"Statistical Learning Theory","author":"Vapnik V. N.","year":"1998"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5b00130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T17:26:34Z","timestamp":1682270794000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5b00130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,2]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7,27]]}},"alternative-id":["10.1021\/acs.jcim.5b00130"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5b00130","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,2]]}}}