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Genet."},{"key":"ref7\/cit7","first-page":"107","volume":"9","author":"Terasaki H.","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1158\/0008-5472.CAN-03-1346","volume":"64","author":"Caldwell G. M.","year":"2004","journal-title":"Cancer Res."},{"key":"ref9\/cit9","first-page":"1219","volume":"10","author":"Okino K.","year":"2003","journal-title":"Oncol. Rep."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"a008052","DOI":"10.1101\/cshperspect.a008052","volume":"4","author":"Polakis P.","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1158\/0008-5472.CAN-12-2258","volume":"73","author":"Proffitt K. D.","year":"2013","journal-title":"Cancer Res."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1242\/jcs.072132","volume":"123","author":"Coombs G. S.","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.devcel.2006.10.003","volume":"11","author":"Takada R.","year":"2006","journal-title":"Dev. Cell"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"17009","DOI":"10.1074\/jbc.M114.561209","volume":"289","author":"Rios-Esteves J.","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nchembio.137","volume":"5","author":"Chen B.","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"12649","DOI":"10.1073\/pnas.1307218110","volume":"110","author":"Jiang X.","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"20224","DOI":"10.1073\/pnas.1314239110","volume":"110","author":"Liu J.","year":"2013","journal-title":"Proc. Natl. 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B"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/(SICI)1096-987X(199905)20:7<720::AID-JCC7>3.0.CO;2-X","volume":"20","author":"Halgren T. A.","year":"1999","journal-title":"J. Comput. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0898-5529(88)90015-2","volume":"1","author":"Hasel W. H.","year":"1988","journal-title":"Tetrahedron Comput. Method."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.1021\/ja00172a038","volume":"112","author":"Still W. C.","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1023\/A:1008007507641","volume":"12","author":"Bostrom J.","year":"1998","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1021\/ja00105a030","volume":"116","author":"Tannor D. J.","year":"1994","journal-title":"J. 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PCT\/US2010\/025813, 2010."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1021\/jm400159c","volume":"56","author":"Wang X.","year":"2013","journal-title":"J. Med. 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