{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:37:51Z","timestamp":1774424271200,"version":"3.50.1"},"reference-count":106,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2015,8,24]]},"DOI":"10.1021\/acs.jcim.5b00240","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T14:16:54Z","timestamp":1438611414000},"page":"1645-1662","source":"Crossref","is-referenced-by-count":55,"title":["Molecular Dynamics Simulations and Structural Network Analysis of c-Abl and c-Src Kinase Core Proteins: Capturing Allosteric Mechanisms and Communication Pathways from Residue Centrality"],"prefix":"10.1021","volume":"55","author":[{"given":"Amanda","family":"Tse","sequence":"first","affiliation":[{"name":"Graduate Program in Computational and Data Sciences,\rDepartment of Computational Sciences, Schmid College of Science and\rTechnology, Chapman University, One University Drive, Orange, California 92866, United States"}]},{"given":"Gennady M.","family":"Verkhivker","sequence":"additional","affiliation":[{"name":"Graduate Program in Computational and Data Sciences,\rDepartment of Computational Sciences, Schmid College of Science and\rTechnology, Chapman University, One University Drive, Orange, California 92866, United States"},{"name":"Chapman University School of Pharmacy, Irvine, California 92618, United States"}]}],"member":"316","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.08.024"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095920"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00741-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.09.006"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-052410-090317"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0054"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3432"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121365"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0015"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2013.02.040"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001680"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00623-2"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00191-0"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1280"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208081"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.171"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8122-2"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/385595a0"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80356-1"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2005.03.012"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00194-6"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.01.035"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00274-0"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.047"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912458584"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R112.438382"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1177\/1947601912462126"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062631007"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051782206"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.431312"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/bi800446b"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-280"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005401200"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204978"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.08.040"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605902200"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.330"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5486.1938"},{"key":"ref39\/cit39","first-page":"4236","volume":"62","author":"Nagar B.","year":"2002","journal-title":"Cancer Res."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040144"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4187"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205017"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.046"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6470"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141492"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314712110"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2012.12.009"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-183665"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2007.01.015"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3953"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21442"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.109660"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/ja210751t"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214330110"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/ja405939x"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/ja504146x"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/cb400663k"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2891"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811223106"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000487"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002179"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003863"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303966110"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1039\/b819720b"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1039\/c3cp54253j"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.65.061910"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122076099"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(04)74086-2"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.physa.2004.08.046"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20348"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti167"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000170"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.10.055"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030117"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062249106"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1038\/msb4100063"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.064485"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.08.079"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704459104"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1021\/bi8007559"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6807-10-27"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1021\/bi200306u"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810961106"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.246702"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120536109"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1021\/ci400044m"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt292"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.07.012"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl113"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1021\/jp973084f"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113488"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23381"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199802)19:3<319::AID-JCC6>3.0.CO;2-W"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt503"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1145\/367766.368168"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg448"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1021\/jp312576v"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21561"},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"1518S","DOI":"10.1093\/jn\/137.6.1518S","volume":"137","author":"Nagar B.","year":"2007","journal-title":"J. Nutr."},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1038\/74041"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.48.32129"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1038\/11537"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1038\/nphys209"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm257"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5b00240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T13:23:49Z","timestamp":1681565029000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5b00240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,12]]},"references-count":106,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8,24]]}},"alternative-id":["10.1021\/acs.jcim.5b00240"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5b00240","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,12]]}}}