{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:41:59Z","timestamp":1767962519402,"version":"3.49.0"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"7","funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 15420"],"award-info":[{"award-number":["IG 15420"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","award":["2011.1800"],"award-info":[{"award-number":["2011.1800"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2015,7,27]]},"DOI":"10.1021\/acs.jcim.5b00270","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T16:36:21Z","timestamp":1435595781000},"page":"1377-1387","source":"Crossref","is-referenced-by-count":28,"title":["Structural Stability and Flexibility Direct the Selection of Activating Mutations in Epidermal Growth Factor Receptor Kinase"],"prefix":"10.1021","volume":"55","author":[{"given":"Antonella","family":"Paladino","sequence":"first","affiliation":[{"name":"Istituto di Chimica del Riconoscimento Molecolare, CNR Via Mario Bianco 9, 20131, Milano, Italy"}]},{"given":"Giulia","family":"Morra","sequence":"additional","affiliation":[{"name":"Istituto di Chimica del Riconoscimento Molecolare, CNR Via Mario Bianco 9, 20131, Milano, Italy"}]},{"given":"Giorgio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Istituto di Chimica del Riconoscimento Molecolare, CNR Via Mario Bianco 9, 20131, Milano, Italy"}]}],"member":"316","published-online":{"date-parts":[[2015,7,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000487"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075762"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1299"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nature05610"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00741-9"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.297"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.063"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.09.006"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b01421"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.013"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/bi400575k"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026071"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418402111"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00966-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220843110"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221953110"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.01.014"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/cb300487u"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ci4005767"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ct700301q"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/1096-987X(200009)21:12<1049::AID-JCC3>3.0.CO;2-F"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.3.CO;2-L"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/jp210568a"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03223804"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21963"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000323"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002433"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.03.033"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2009.08.003"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169375"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002179"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.030"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ja210751t"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nature05998"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.03.004"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/376313a0"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.06.001"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5b00270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T17:27:19Z","timestamp":1682270839000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5b00270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,10]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7,27]]}},"alternative-id":["10.1021\/acs.jcim.5b00270"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5b00270","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,10]]}}}