{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:34:28Z","timestamp":1760027668630},"reference-count":24,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2016,2,22]]},"DOI":"10.1021\/acs.jcim.5b00713","type":"journal-article","created":{"date-parts":[[2016,2,3]],"date-time":"2016-02-03T01:18:27Z","timestamp":1454462307000},"page":"300-307","source":"Crossref","is-referenced-by-count":17,"title":["Assessing the Growth of Bioactive Compounds and Scaffolds over Time: Implications for Lead Discovery and Scaffold Hopping"],"prefix":"10.1021","volume":"56","author":[{"given":"Swarit","family":"Jasial","sequence":"first","affiliation":[{"name":"Department of Life Science\rInformatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal\rChemistry, Rheinische Friedrich-Wilhelms-Universit\u00e4t, Dahlmannstr. 2, D-53113 Bonn, Germany"}]},{"given":"Ye","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Life Science\rInformatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal\rChemistry, Rheinische Friedrich-Wilhelms-Universit\u00e4t, Dahlmannstr. 2, D-53113 Bonn, Germany"}]},{"given":"J\u00fcrgen","family":"Bajorath","sequence":"additional","affiliation":[{"name":"Department of Life Science\rInformatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal\rChemistry, Rheinische Friedrich-Wilhelms-Universit\u00e4t, Dahlmannstr. 2, D-53113 Bonn, Germany"}]}],"member":"316","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.12.004"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.02.004"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2857"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.03.002"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2787"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9421-y"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.5250.2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1228"},{"key":"ref9\/cit9","first-page":"297","volume":"13","author":"Boran A. D.","year":"2010","journal-title":"Curr. Opin. Drug Discovery Dev."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/C2MD20242E"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ci200179y"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/jm9602928"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/ci600338x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/ci0003911"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.14.156"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503647102"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ci2001428"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/jm4017625"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19991004)38:19<2894::AID-ANIE2894>3.0.CO;2-F"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1106"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr777"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"D71","DOI":"10.1093\/nar\/gkr981","volume":"40","author":"UniProtConsortium.","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref23\/cit23","volume-title":"OEChem","year":"2012"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/c0md00156b"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5b00713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T08:33:45Z","timestamp":1682152425000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5b00713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,10]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2,22]]}},"alternative-id":["10.1021\/acs.jcim.5b00713"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5b00713","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,10]]}}}