{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:36:38Z","timestamp":1781058998902,"version":"3.54.1"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100011706","name":"National Agri-Food Biotechnology Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011706","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,7,14]]},"DOI":"10.1021\/acs.jcim.5c00465","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:04:32Z","timestamp":1750118672000},"page":"7193-7208","source":"Crossref","is-referenced-by-count":6,"title":["Predicting Biological Activity from Biosynthetic Gene Clusters Using Neural Networks"],"prefix":"10.1021","volume":"65","author":[{"given":"Hemant","family":"Goyat","sequence":"first","affiliation":[{"name":"Computational Biology Lab, National Agri-Food Biotechnology Institute, Sector 81, SAS Nagar, Punjab 140308, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-4435","authenticated-orcid":true,"given":"Dalwinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology","place":["London, Canada"]},{"name":"Western University","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunaina","family":"Paliyal","sequence":"additional","affiliation":[{"name":"Computational Biology Lab, National Agri-Food Biotechnology Institute, Sector 81, SAS Nagar, Punjab 140308, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant","family":"Mantri","sequence":"additional","affiliation":[{"name":"Computational Biology Lab, National Agri-Food Biotechnology Institute, Sector 81, SAS Nagar, Punjab 140308, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1890"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","unstructured":"Demain, A. L.; Fang, A.\n                      The Natural Functions of Secondary Metabolites\n                      ; Springer, 2000; pp 1\u201339.","DOI":"10.1007\/3-540-44964-7_1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1132555"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-004-1812-2"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-397922-3.00002-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.8b00760"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00834-2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-023-00774-7"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00032B"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz310"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz654"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx320"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-169"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx408"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2319"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49764-z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901493116"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky383"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa812"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c01304"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03400-23"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00043D"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1049"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad344"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt006"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1306"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1092"},{"key":"ref28\/cit28","volume-title":"Deep Learning","author":"Goodfellow I.","year":"2016"},{"key":"ref29\/cit29","volume-title":"Deep Learning: A Practitioner\u2019s Approach","author":"Patterson J.","year":"2017"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","unstructured":"Ravikumar, N.; Zakeri, A.; Xia, Y.; Frangi, A. F.\n                      Medical Image Analysis\n                      ; Elsevier, 2024; 415\u2013450.","DOI":"10.1016\/B978-0-12-813657-7.00041-8"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1606.08415"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.asoc.2019.105524"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2015.04.015"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2023.168018"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz935"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-020-00338-8"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2019.2911071"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.inffus.2021.11.011"},{"key":"ref39\/cit39","first-page":"507","volume":"35","author":"Grinsztajn L.","year":"2022","journal-title":"Adv Neural Inf Process Syst"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-3702(97)00043-X"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202645"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-021-00465-8"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07911-2"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/np100352e"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/md14040073"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/jimb\/kuab007"},{"key":"ref47\/cit47","first-page":"5857","volume":"35","author":"Kounnis V.","year":"2015","journal-title":"Anticancer Res"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-023-03840-9"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c00234"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00072-23"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00283"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00061F"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00046"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19986-1"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2306.15006"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02523-z"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00465","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T07:27:30Z","timestamp":1752910050000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c00465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,17]]},"references-count":57,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7,14]]}},"alternative-id":["10.1021\/acs.jcim.5c00465"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c00465","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.06.20.599829","asserted-by":"object"}]},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,17]]}}}