{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:53:14Z","timestamp":1776826394947,"version":"3.51.2"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62475177"],"award-info":[{"award-number":["62475177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan International Science and Technology Innovation Cooperation Project","award":["2024YFHZ0328"],"award-info":[{"award-number":["2024YFHZ0328"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,7,28]]},"DOI":"10.1021\/acs.jcim.5c00473","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T20:34:06Z","timestamp":1751920446000},"page":"7584-7604","source":"Crossref","is-referenced-by-count":6,"title":["TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms"],"prefix":"10.1021","volume":"65","author":[{"given":"Liyun","family":"Zhang","sequence":"first","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]},{"name":"College of Chemistry","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}]},{"given":"Qingyang","family":"Wang","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Xiaomei","family":"Li","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Xuemin","family":"Cheng","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Longying","family":"Cai","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Anping","family":"Guo","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Lanjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Hong","family":"Hu","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Mei","family":"Wu","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Xianyang","family":"Li","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Huilin","family":"Li","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Xiaoyun","family":"Meng","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Yaping","family":"Qiu","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Guiping","family":"Tu","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Lifang","family":"Zhang","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Xiaofei","family":"Dong","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Yu","family":"Liang","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Yushuang","family":"Wang","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2964-7759","authenticated-orcid":true,"given":"Dengfeng","family":"Dou","sequence":"additional","affiliation":[{"name":"HitGen Inc.","place":["Chengdu, China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-4258","authenticated-orcid":true,"given":"Xuemei","family":"Pu","sequence":"additional","affiliation":[{"name":"College of Chemistry","place":["Chengdu, China"]},{"name":"Sichuan University","place":["Chengdu, China"]}]}],"member":"316","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00966-4"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.031"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b01068"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0055-y"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2329"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39904-5"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-arplant-042809-112256"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0047-y"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42233-2"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.4c00833"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0028-3"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37504-x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21443-6"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.10.015"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00603"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.02.042"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2024.10.006"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.106212"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0261"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2006.03.003"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01154"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c01036"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-022-00527-y"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1088\/2632-2153\/abcf91"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34807-3"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00897"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01576"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c01451"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00589"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33575-4"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1063\/1.5055799"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.4c04857"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.3c05284"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c01024"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131902"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1521"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00198G"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks976"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16580"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0915-9"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112426"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nature09504"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4131"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.2c00797"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01846"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btae416"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914396"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-022-02327-5"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c02155"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.26434\/chemrxiv-2024-gtvz9"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609174104"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08027-7"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-015-9840-9"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1063\/1.2978177"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2015.08.015"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00740"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00358"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(03)00250-2"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp447"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/prot.25278"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1121"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01153"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1032936"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c00415"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.133374"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00425"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00055"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.200600527"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-022-01030-9"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00473","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T08:11:03Z","timestamp":1753690263000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c00473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":72,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,7,28]]}},"alternative-id":["10.1021\/acs.jcim.5c00473"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c00473","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]}}}