{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:10:29Z","timestamp":1779149429049,"version":"3.51.4"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2024B1111160007"],"award-info":[{"award-number":["2024B1111160007"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20220818100804010"],"award-info":[{"award-number":["JCYJ20220818100804010"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23HC1400500"],"award-info":[{"award-number":["23HC1400500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22201295"],"award-info":[{"award-number":["22201295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272269"],"award-info":[{"award-number":["32272269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education","award":["2024KF04"],"award-info":[{"award-number":["2024KF04"]}]},{"name":"Key Laboratory of Industrial Microbiology, Tianjin University of Science & Technology","award":["2024KF04"],"award-info":[{"award-number":["2024KF04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,5,26]]},"DOI":"10.1021\/acs.jcim.5c00534","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T18:34:11Z","timestamp":1746642851000},"page":"4878-4888","source":"Crossref","is-referenced-by-count":4,"title":["MTPSol: Multimodal Twin Protein Solubility Prediction Architecture Based on Pretrained Models"],"prefix":"10.1021","volume":"65","author":[{"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin; Key Laboratory of Industrial Microbiology, College of Biotechnology","place":["Tianjin, P. R. China"]},{"name":"Tianjin University of Science and Technology","place":["Tianjin, P. R. China"]},{"name":"Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology","place":["Shenzhen, People\u2019s Republic of China"]},{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongkui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Landong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology","place":["Shenzhen, People\u2019s Republic of China"]},{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fufeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin; Key Laboratory of Industrial Microbiology, College of Biotechnology","place":["Tianjin, P. R. China"]},{"name":"Tianjin University of Science and Technology","place":["Tianjin, P. R. China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology","place":["Shenzhen, People\u2019s Republic of China"]},{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, People\u2019s Republic of China"]},{"name":"School of Food Science and Pharmaceutical Engineering","place":["Nanjing, People\u2019s Republic of China"]},{"name":"Nanjing Normal University","place":["Nanjing, People\u2019s Republic of China"]},{"name":"State Key Laboratory of Microbial Technology","place":["Nanjing, People\u2019s Republic of China"]},{"name":"Nanjing Normal University","place":["Nanjing, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3508-1337","authenticated-orcid":true,"given":"Yang","family":"Gu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology","place":["Shenzhen, People\u2019s Republic of China"]},{"name":"Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00044-z"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbt057"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15544"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202100031"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb70033j"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06415-8"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02437-w"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06415-8"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.15544"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202100031"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.127746"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112197108"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl623"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp386"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.005"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa1102"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty166"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab463"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413555"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-023-01510-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-021-00488-1"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","unstructured":"Tan, Y.; Zheng, J.; Hong, L.; Zhou, B. PROTSOLM: Protein Solubility Prediction with Multi-modal Features.  2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2024; IEEE, 2024; pp 223\u2013232.","DOI":"10.1109\/BIBM62325.2024.10822310"},{"key":"ref24\/cit24","unstructured":"Berman, H. M.; Gabanyi, M. J.; Kouranov, A.; Micallef, D.; Westbrook, J. Protein Structure Initiative\u2013Targettrack 2000\u20132017\u2013All Data Files; Zenodo, 2017; p 10."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3988"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/2042-5783-1-6"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg520"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1061"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1101\/2022.07.20.500902"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/C6GC02328B"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188934"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.13940"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa977"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2015.04.015"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"ref37\/cit37","first-page":"29287","volume":"34","author":"Meier J.","year":"2021","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1126\/science.add2187"},{"key":"ref39\/cit39","first-page":"arXiv:1508.0402","author":"Luong M.-T.","year":"2015","journal-title":"arXiv"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1109\/tpami.2018.2876404"},{"key":"ref41\/cit41","first-page":"30","volume":"2017","author":"Waswani A.","year":"2017","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","unstructured":"Lin, T.Y.; Goyal, P.; Girshick, R.; He, K.; Doll\u00e1r, P. Focal loss for dense object detection.  Proceedings of the IEEE International Conference on Computer Vision; IEEE, 2017; Vol 2017, pp 2980\u20132988.","DOI":"10.1109\/ICCV.2017.324"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2014.09.026"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx345"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007722"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab801"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.107918"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00534","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T08:11:35Z","timestamp":1748247095000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c00534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,7]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5,26]]}},"alternative-id":["10.1021\/acs.jcim.5c00534"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c00534","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,7]]}}}