{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:56:35Z","timestamp":1774061795185,"version":"3.50.1"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100009023","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JPMJPR20AB"],"award-info":[{"award-number":["JPMJPR20AB"]}],"id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18K14391"],"award-info":[{"award-number":["18K14391"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21K05395"],"award-info":[{"award-number":["21K05395"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23K19283"],"award-info":[{"award-number":["23K19283"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24H01153"],"award-info":[{"award-number":["24H01153"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24K17828"],"award-info":[{"award-number":["24K17828"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["25H01588"],"award-info":[{"award-number":["25H01588"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["25H01589"],"award-info":[{"award-number":["25H01589"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,6,23]]},"DOI":"10.1021\/acs.jcim.5c00624","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T03:31:42Z","timestamp":1749094302000},"page":"6331-6340","source":"Crossref","is-referenced-by-count":1,"title":["GArNet: A Genetic Algorithm-Based Protein Redesign Approach to Optimize Mutation Combinations Informed by Network Theory"],"prefix":"10.1021","volume":"65","author":[{"given":"Hiroki","family":"Ozawa","sequence":"first","affiliation":[{"name":"Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}]},{"given":"Shoryu","family":"Fujita","sequence":"additional","affiliation":[{"name":"Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8584-5368","authenticated-orcid":true,"given":"Taichi","family":"Chisuga","sequence":"additional","affiliation":[{"name":"Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6614-7158","authenticated-orcid":true,"given":"Shogo","family":"Nakano","sequence":"additional","affiliation":[{"name":"Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan"}]}],"member":"316","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c01496"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020902)41:17<3177::AID-ANIE3177>3.0.CO;2-P"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201410670"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b03418"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2025.111295"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/bm801386j"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/aem.01831-24"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006648"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c05265"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b03613"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02127-0"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.add2187"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06415-8"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10941"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202414705"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b11323"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816707116"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2021.04.001"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19695-9"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308215110"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.102435"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.77.062906.171838"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00442-4"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.06.012"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004556"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101758"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq007"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.4161\/bioe.23041"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09749-2"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.509"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1267"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200390033"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024182228057"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70765"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/s00449-008-0198-4"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00571"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1128\/JB.185.15.4483-4489.2003"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.336958"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07916.x"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.540773"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2015.10.014"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12351"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2336"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.11.003"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.8b00339"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.1c00309"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.0c00570"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019102864"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(98)77529-0"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202404880"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzr030"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00624","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:33:35Z","timestamp":1768566815000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c00624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6,23]]}},"alternative-id":["10.1021\/acs.jcim.5c00624"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c00624","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}