{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:03:06Z","timestamp":1775581386071,"version":"3.50.1"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20242073"],"award-info":[{"award-number":["BK20242073"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073704"],"award-info":[{"award-number":["82073704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173692"],"award-info":[{"award-number":["82173692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,6,23]]},"DOI":"10.1021\/acs.jcim.5c00817","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:55:04Z","timestamp":1749182104000},"page":"5921-5933","source":"Crossref","is-referenced-by-count":3,"title":["MTGNN: A Drug\u2013Target\u2013Disease Triplet Association Prediction Model Based on Multimodal Heterogeneous Graph Neural Networks and Direction-Aware Metapaths"],"prefix":"10.1021","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9020-4980","authenticated-orcid":true,"given":"Lidan","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Simeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1178-8570","authenticated-orcid":true,"given":"Yihao","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy","place":["Chongqing, China"]},{"name":"Chongqing Medical University","place":["Chongqing, China"]}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Qian","family":"Ge","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Lingxi","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3621-2403","authenticated-orcid":true,"given":"Yu","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Yunfei","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Junfei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Mengyi","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Public Health","place":["Nanjing, China"]},{"name":"Nanjing Medical University","place":["Nanjing, China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2189-9356","authenticated-orcid":true,"given":"Yadong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0701-343X","authenticated-orcid":true,"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]},{"given":"Haichun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Science","place":["Nanjing, China"]},{"name":"China Pharmaceutical University institution","place":["Nanjing, China"]}]}],"member":"316","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03632-9"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa003"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1468"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.168"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28858"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty593"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty543"},{"key":"ref8\/cit8","author":"Kipf T. N.","year":"2016","journal-title":"arXiv"},{"key":"ref9\/cit9","author":"Veli\u010dkovi\u0107 P.","year":"2018","journal-title":"arXiv"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1145\/3366423.3380297"},{"key":"ref11\/cit11","first-page":"6000","volume-title":"NIPS\u201917: Proceedings of the 31st International Conference on Neural Information Processing Systems","author":"Vaswani A.","year":"2017"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007129"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa880"},{"key":"ref14\/cit14","author":"Zhang P.-D.","year":"2024","journal-title":"bioRxiv"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab715"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2025.110239"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2024.124647"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2023.107621"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1049\/cit2.12194"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-019-3283-6"},{"key":"ref21\/cit21","first-page":"3452","volume-title":"IJCAI\u201920: Proceedings of the Twenty-Ninth International Conference on International Joint Conferences on Artificial Intelligence","author":"Chen H.","year":"2021"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1145\/3308558.3313476"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btac579"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1145\/3308558.3313562"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad079"},{"key":"ref26\/cit26","author":"Zhang K.","year":"2024","journal-title":"arXiv"},{"key":"ref27\/cit27","author":"Sun Z.","year":"2019","journal-title":"arXiv"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2574"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1109\/ICME52920.2022.9859720"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV48922.2021.00041"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa891"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"ref34\/cit34","volume-title":"An Elementary Mathematical Theory of Classification and Prediction","author":"Tanimoto T. T.","year":"1958"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn162"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq241"},{"key":"ref37\/cit37","first-page":"3452","volume-title":"IJCAI\u201920: Proceedings of the Twenty-Ninth International Conference on International Joint Conferences on Artificial Intelligence","author":"Chen H.","year":"2021"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1137\/07070111X"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2023.107844"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btae347"},{"key":"ref41\/cit41","first-page":"1112","volume-title":"Proceedings of the Twenty-Eighth AAAI Conference on Artificial Intelligence","author":"Wang Z.","year":"2014"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.18653\/v1\/2021.acl-long.336"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2024.128614"},{"key":"ref44\/cit44","author":"Chithrananda S.","year":"2020","journal-title":"arXiv"},{"issue":"86","key":"ref45\/cit45","first-page":"2579","volume":"9","author":"van der Maaten L.","year":"2008","journal-title":"J. Mach. Learn. Res."},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/cells11244032"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02034-4"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1089\/107555303321223035"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00680-8"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00817","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c00817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T08:10:37Z","timestamp":1750666237000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c00817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,5]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,6,23]]}},"alternative-id":["10.1021\/acs.jcim.5c00817"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c00817","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,5]]}}}