{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T11:27:22Z","timestamp":1769945242423,"version":"3.49.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"20","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100016109","name":"Taishan Industry Leading Talents","doi-asserted-by":"publisher","award":["tscx202306145"],"award-info":[{"award-number":["tscx202306145"]}],"id":[{"id":"10.13039\/501100016109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M731167"],"award-info":[{"award-number":["2023M731167"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202406790100"],"award-info":[{"award-number":["202406790100"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62176105"],"award-info":[{"award-number":["62176105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yellow River Delta Industrial Leading Talent Program","award":["DYRC20200205"],"award-info":[{"award-number":["DYRC20200205"]}]},{"name":"Basic Research Funds for Central Universities - Zhishan Young Scholars Program","award":["JUSRP622016"],"award-info":[{"award-number":["JUSRP622016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,10,27]]},"DOI":"10.1021\/acs.jcim.5c01674","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:44:34Z","timestamp":1759319074000},"page":"10932-10944","source":"Crossref","is-referenced-by-count":2,"title":["Modeling Enzyme Temperature Stability from Sequence Segment Perspective"],"prefix":"10.1021","volume":"65","author":[{"given":"Ziqi","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Artificial Intelligence and Computer Science","place":["Wuxi, China"]},{"name":"Jiangnan University","place":["Wuxi, China"]}]},{"given":"Shiheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology and State Key Laboratory of Food Science and Resources","place":["Wuxi, China"]},{"name":"Jiangnan University","place":["Wuxi, China"]}]},{"given":"Runze","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Computing","place":["Sydney, Australia"]},{"name":"Macquarie Universityy","place":["Sydney, Australia"]},{"name":"Institute of Image Processing and Pattern Recognition, and Key Laboratory of System Control and Information Processing, Ministry of Education of China","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University","place":["Shanghai, China"]}]},{"given":"Zhisheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology and State Key Laboratory of Food Science and Resources","place":["Wuxi, China"]},{"name":"Jiangnan University","place":["Wuxi, China"]}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Artificial Intelligence and Computer Science","place":["Nantong, China"]},{"name":"Nantong University","place":["Nantong, China"]}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology and State Key Laboratory of Food Science and Resources","place":["Wuxi, China"]},{"name":"Jiangnan University","place":["Wuxi, China"]}]},{"given":"Zhanzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology and State Key Laboratory of Food Science and Resources","place":["Wuxi, China"]},{"name":"Jiangnan University","place":["Wuxi, China"]},{"name":"Shandong Huatai Paper Co. Ltd and Shandong Yellow Triangle Biotechnology Industry Research Institute Co. Ltd","place":["Dongying, China"]}]},{"given":"Fengshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Huatai Paper Co. Ltd and Shandong Yellow Triangle Biotechnology Industry Research Institute Co. Ltd","place":["Dongying, China"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8861-766X","authenticated-orcid":true,"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Biotechnology, Ministry of Education and School of Biotechnology and State Key Laboratory of Food Science and Resources","place":["Wuxi, China"]},{"name":"Jiangnan University","place":["Wuxi, China"]},{"name":"Shandong Huatai Paper Co. Ltd and Shandong Yellow Triangle Biotechnology Industry Research Institute Co. Ltd","place":["Dongying, China"]}]},{"given":"Xiaoyong","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Image Processing and Pattern Recognition, and Key Laboratory of System Control and Information Processing, Ministry of Education of China","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University","place":["Shanghai, China"]}]},{"given":"Hongbin","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Image Processing and Pattern Recognition, and Key Laboratory of System Control and Information Processing, Ministry of Education of China","place":["Shanghai, China"]},{"name":"Shanghai Jiao Tong University","place":["Shanghai, China"]}]},{"given":"Longbing","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Computing","place":["Sydney, Australia"]},{"name":"Macquarie Universityy","place":["Sydney, Australia"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-6492","authenticated-orcid":true,"given":"Zhaohong","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Artificial Intelligence and Computer Science","place":["Wuxi, China"]},{"name":"Jiangnan University","place":["Wuxi, China"]}]}],"member":"316","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(01)01803-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s00792-007-0089-7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.05.001"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-354-1_13"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2019.1682963"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1010"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1025"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2174\/092986612798472794"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.4236\/jbise.2019.128033"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2225\/vol15-issue1-fulltext-8"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcatb.2016.04.005"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27608"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.9b00099"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c00489"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.3c06526"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4480"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s40643-022-00543-1"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaf114"},{"key":"ref19\/cit19","author":"Elnaggar A.","year":"2021","journal-title":"arXiv"},{"key":"ref20\/cit20","first-page":"500902","volume":"2022","author":"Lin Z.","year":"2022","journal-title":"bioRxiv"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043700"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112751"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/13.11.753"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx285"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl163"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.06.012"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-025-01026-6"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3988"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2574"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1109\/TCBBIO.2025.3552846"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5c00526"},{"key":"ref32\/cit32","first-page":"2579","volume":"9","author":"van der Maaten L.","year":"2008","journal-title":"J. Mach. Learn. Res."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.05.037"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ct400341p"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1109\/78.650093"},{"key":"ref36\/cit36","first-page":"2493","volume":"12","author":"Collobert R.","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"ref37\/cit37","volume-title":"Advances in Neural Information Processing Systems","volume":"30","author":"Vaswani A.","year":"2017"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbab035"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1207\/s15516709cog1402_1"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btae157"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-98667-9"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.11.006"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-010-2533-3"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/prot.24955"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0134(199612)26:4<442::AID-PROT5>3.0.CO;2-D"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/bi00019a020"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(99)00159-6"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01183-4"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2006.12.028"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2013.09.005"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/bit.24930"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c01674","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c01674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:12:14Z","timestamp":1761552734000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c01674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":51,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,10,27]]}},"alternative-id":["10.1021\/acs.jcim.5c01674"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c01674","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}