{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T22:54:10Z","timestamp":1768604050769,"version":"3.49.0"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000046","name":"National Research Council Canada","doi-asserted-by":"publisher","award":["AQC203"],"award-info":[{"award-number":["AQC203"]}],"id":[{"id":"10.13039\/501100000046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JPMXP1122714694"],"award-info":[{"award-number":["JPMXP1122714694"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010690","name":"Toyota Physical and Chemical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H02677"],"award-info":[{"award-number":["19H02677"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H0173"],"award-info":[{"award-number":["22H0173"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H05089"],"award-info":[{"award-number":["22H05089"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24H00282"],"award-info":[{"award-number":["24H00282"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K01434"],"award-info":[{"award-number":["24K01434"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25H00913"],"award-info":[{"award-number":["25H00913"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJAP2315"],"award-info":[{"award-number":["JPMJAP2315"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2026,1,12]]},"DOI":"10.1021\/acs.jcim.5c01784","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:10:39Z","timestamp":1761070239000},"page":"518-528","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Disruptive Mechanism of Local Anesthetics on Raft-Like Ordered Membranes: Simulation Studies"],"prefix":"10.1021","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8797-3048","authenticated-orcid":true,"given":"Sirin","family":"Sittiwanichai","sequence":"first","affiliation":[{"name":"Department of Complex Systems Science, Graduate School of Informatics, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3211-735X","authenticated-orcid":true,"given":"Kodai","family":"Kanemaru","sequence":"additional","affiliation":[{"name":"Department of Complex Systems Science, Graduate School of Informatics, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan"},{"name":"Fukui Institute for Fundamental Chemistry, Kyoto University, Takano-Nishibirakicho 34-4, Kyoto, Sakyo-ku, 606-8103, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-431X","authenticated-orcid":true,"given":"Masanao","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of Pure and Applied Science, Faculty of Science and Technology, Gunma University, 4-2 Aramaki cho, Maebashi, Gunma 371-8510, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-2044","authenticated-orcid":true,"given":"Nobuaki","family":"Matsumori","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Graduate School of Science, Kyushu University, 744 Motooka, Fukuoka, Nishi-ku, 819-0395, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2023-7254","authenticated-orcid":true,"given":"Norio","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Complex Systems Science, Graduate School of Informatics, Nagoya University, Furocho, Chikusa, Nagoya 464-8601, Japan"}]}],"member":"316","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.837088"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199004000-00022"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)28443-9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/srep07534"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef163"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1124\/molpharm.121.000252"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2014.08.001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(72)90051-X"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2004.12.003"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/bi00413a012"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-4622(02)00202-8"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.8b10232"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(75)90137-6"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-022-00240-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(84)90496-6"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02290307"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00366"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/00268970902926238"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2344\/0003-3006(2006)53[98:EOLAP]2.0.CO;2"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/S0307-4412(97)00119-2"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.2116\/analsci.17.65"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199008000-00008"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/297141"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/bi00527a013"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2006.10.005"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2014.11.022"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.133637"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.32.110601.141803"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ics.2005.06.077"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.2142\/biophysics.9.37"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908987106"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.1c05438"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2019.06.008"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109057"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/membranes11080579"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200404000-00029"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1063\/1.471557"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jp971083h"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2614(98)00471-0"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1063\/1.478883"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00389"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1088\/1757-899X\/773\/1\/012062"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.27340"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.2c01246"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/jp003020w"},{"key":"ref46\/cit46","volume-title":"GaussView, Version 6.0.16","author":"Dennington R.","year":"2016"},{"key":"ref47\/cit47","volume-title":"Gaussian 16, Revision C.01","author":"Frisch M. J.","year":"2016"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01153"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"ref50\/cit50","author":"Case D. A.","year":"2024","journal-title":"Amber 2024: Reference Manual"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(77)90098-5"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/ct400341p"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540130812"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1063\/1.481565"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref56\/cit56","author":"Turner P. J.","year":"2005","journal-title":"XMGRACE, Version. 5.1.19. Center for Coastal and Land-Margin Research"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2017.03.006"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.07.014"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2004.03.002"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2011.08.007"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2008.07.023"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/0927-7765(95)01228-1"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.10520\/EJC97511"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-016-1164-8"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.104208"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(92)90039-O"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/jp074037i"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2013.12.034"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1080\/08927022.2022.2053118"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c01784","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c01784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:09:21Z","timestamp":1768565361000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c01784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,12]]}},"alternative-id":["10.1021\/acs.jcim.5c01784"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c01784","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,21]]}}}