{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:14:53Z","timestamp":1777983293851,"version":"3.51.4"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001777","name":"University of Wollongong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001777","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2007778"],"award-info":[{"award-number":["2007778"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE230100021"],"award-info":[{"award-number":["CE230100021"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP240101399"],"award-info":[{"award-number":["DP240101399"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2026,3,9]]},"DOI":"10.1021\/acs.jcim.5c02969","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T03:48:47Z","timestamp":1772077727000},"page":"2879-2888","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Insights into Nanobody-Based Quenchbody Sensing via Structural Modeling and Molecular Simulations"],"prefix":"10.1021","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6856-6332","authenticated-orcid":true,"given":"Nehad S.","family":"El Salamouni","sequence":"first","affiliation":[{"name":"School of Science","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"Molecular Horizons","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"ARC Centre of Excellence in Quantum Biotechnology","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan H.","family":"Cater","sequence":"additional","affiliation":[{"name":"School of Science","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"Molecular Horizons","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Science","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"Molecular Horizons","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"ARC Centre of Excellence in Quantum Biotechnology","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5511-8757","authenticated-orcid":true,"given":"Lisanne M.","family":"Spenkelink","sequence":"additional","affiliation":[{"name":"School of Science","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"Molecular Horizons","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-2803","authenticated-orcid":true,"given":"Haibo","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Science","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"Molecular Horizons","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]},{"name":"ARC Centre of Excellence in Quantum Biotechnology","place":["Wollongong, Australia"]},{"name":"University of Wollongong","place":["Wollongong, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/363446a0"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-063011-092449"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13850"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012921"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15515"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/prot.25497"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34317"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05241-y"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1050"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1101\/2025.07.01.662355"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c01877"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbv027"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzy017"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1101\/2024.10.10.615955"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1101\/2024.11.19.624167"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.08.631967"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1101\/2025.07.25.666870"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2025.2545601"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2412.09826"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.04.463034"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2404.10260"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2408.16975"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08359-3"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.0c01404"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/s21041223"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3562"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5075"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0996-803"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nature01870"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413011200"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.07.038"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505379103"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.614842"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50722-y"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110268"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/bmb.2002.494030030035"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","unstructured":"Lakowicz, J. R.\n                      Quenching of fluorescence\n                      . Springer: In Principles of fluorescence spectroscopy, 1983; pp 257\u2013301.","DOI":"10.1007\/978-1-4615-7658-7_9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c00243"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.200500191"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.200900238"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/bc0341324"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/ja036082j"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502655"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae241"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btae586"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161879"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20945"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21367"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1063\/5.0014475"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ct100578z"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2614(84)80098-6"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1063\/1.470648"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/ct5010406"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9991(83)90014-1"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21787"},{"issue":"1","key":"ref62\/cit62","first-page":"82","volume":"40","author":"DeLano W. L.","year":"2002","journal-title":"CCP4 Newsl. protein crystallogr"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/ct400341p"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080635"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c02969","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c02969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:41:22Z","timestamp":1773128482000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c02969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3,9]]}},"alternative-id":["10.1021\/acs.jcim.5c02969"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c02969","relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-c5z4k","asserted-by":"object"},{"id-type":"doi","id":"10.26434\/chemrxiv-2025-c5z4k\/v2","asserted-by":"object"}]},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]}}}