{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:25:36Z","timestamp":1775708736049,"version":"3.50.1"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"12","funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2011\/03\/B\/NZ1\/03204"],"award-info":[{"award-number":["2011\/03\/B\/NZ1\/03204"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2016,12,27]]},"DOI":"10.1021\/acs.jcim.6b00499","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T16:14:43Z","timestamp":1480349683000},"page":"2457-2466","source":"Crossref","is-referenced-by-count":31,"title":["Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor"],"prefix":"10.1021","volume":"56","author":[{"given":"Jakub","family":"Jakowiecki","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-3858","authenticated-orcid":true,"given":"Slawomir","family":"Filipek","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, ul. Pasteura 1, 02-093 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","volume":"54","author":"Howlett A. C.","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/C4MD00121D"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.02.058"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00739"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.08.048"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2013.01.009"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215904"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.002"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"5.6.1","DOI":"10.1002\/0471250953.bi0506s47","volume":"47","author":"Webb B.","year":"2014","journal-title":"Curr. Protoc. Bioinf."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056742"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.23899"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20817"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2174\/156802610791164210"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.261651"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ci3003649"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21287"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20945"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00935"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/ci400766b"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-9471(05)80049-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600630705"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-011-0986-7"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799320556"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00581"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391861-1.00016-2"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2553"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1247"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076535"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004382"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.041590"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0031-6997(25)06863-2","volume":"38","author":"Razdan R. K.","year":"1986","journal-title":"Pharmacol. Rev."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13250"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.6b00499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T22:17:21Z","timestamp":1749766641000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.6b00499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12,27]]}},"alternative-id":["10.1021\/acs.jcim.6b00499"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.6b00499","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,14]]}}}