{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:33:33Z","timestamp":1786365213763,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20241202130212016"],"award-info":[{"award-number":["JCYJ20241202130212016"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12426303"],"award-info":[{"award-number":["12426303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62272449"],"award-info":[{"award-number":["62272449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20257"],"award-info":[{"award-number":["U24A20257"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["CKL075"],"award-info":[{"award-number":["CKL075"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008865","name":"Xiamen University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720250172"],"award-info":[{"award-number":["20720250172"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory","doi-asserted-by":"publisher","award":["2025XAKJ0102017"],"award-info":[{"award-number":["2025XAKJ0102017"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Shenzhen University of Advanced Technology","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>RNA 2\u2032-O-methylation (2OMe) is a widespread post-transcriptional modification that influences RNA stability, translation, and immune recognition. Yet, accurate computational identification of 2OMe sites remains challenging because conventional sequence encodings incompletely capture contextual dependencies and higher-order sequence patterns. Here, we present Caps-2OMe, an interpretable multimodal deep learning framework that combines a Chaos Game Representation (CGR) branch to encode positional and compositional sequence patterns with an RNA-FM branch to capture context-aware sequence representations and long-range dependencies. The two feature streams are adaptively fused and decoded by a capsule-based architecture for robust 2OMe site prediction. Caps-2OMe achieved an accuracy of 0.936 and an AUC of 0.987 on the independent test set, outperforming existing computational predictors. Capsule-level analyses further revealed sparse and class-specific routing patterns, while digit capsule length provided a meaningful estimate of prediction confidence. Motif analysis further revealed biologically meaningful sequence signatures, including an AGAUC-like dominant motif and a CU-enriched local sequence context. Cross-nucleotide evaluation showed that the general model remained stable across four subsets, whereas subtype-specific models exhibited limited transferability. These results establish Caps-2OMe as an accurate and interpretable framework for 2OMe site prediction and provide a useful framework for advancing the computational study of RNA modifications and their regulatory roles.<\/jats:p>","DOI":"10.1021\/acs.jcim.6c01274","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:19:28Z","timestamp":1781551168000},"page":"9651-9662","source":"Crossref","is-referenced-by-count":0,"title":["An Interpretable\nDeep Learning Framework Leveraging\nRNA Foundation Model and Capsule Networks for Accurate Prediction\nof RNA 2\u2032-O-Methylation Sites"],"prefix":"10.1021","volume":"66","author":[{"given":"Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]},{"name":"The Chinese University of Hong Kong, Shenzhen , , 2001 Longxiang Road , ,","place":["Shenzhen, China, 518172"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Shi","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Gu","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong, Shenzhen , , 2001 Longxiang Road , ,","place":["Shenzhen, China, 518172"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingchen","family":"Liu","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong, Shenzhen , , 2001 Longxiang Road , ,","place":["Shenzhen, China, 518172"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"National Yang Ming Chiao Tung University , , ,","place":["Hsinchu, Taiwan, 300093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-190X","authenticated-orcid":true,"given":"Leyi","family":"Wei","sequence":"additional","affiliation":[{"name":"Macao Polytechnic University , , R. de Lui\u0301s Gonzaga Gomes , ,","place":["Macao, China, 999078"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0584-0637","authenticated-orcid":true,"given":"Jiahui","family":"Guan","sequence":"additional","affiliation":[{"name":"The University of Hong Kong , , ,","place":["Hong Kong, China, 999077"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Xie","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong, Shenzhen , , 2001 Longxiang Road , ,","place":["Shenzhen, China, 518172"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijun","family":"Tang","sequence":"additional","affiliation":[{"name":"Shenzhen University of Advanced Technology , , ,","place":["Shenzhen, China, 518107"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-6827","authenticated-orcid":true,"given":"Lantian","family":"Yao","sequence":"additional","affiliation":[{"name":"Xiamen University , , ,","place":["Xiamen, China, 361005"]},{"name":"Shenzhen University of Advanced Technology , , ,","place":["Shenzhen, China, 518107"]},{"name":"Xiamen University , , ,","place":["Xiamen, China, 361102"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"issue":"1","key":"2026081008101717400_cit1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrm.2016.132","article-title":"Post-transcriptional gene regulation\nby mrna modifications","volume":"18","author":"Zhao","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"2026081008101717400_cit2","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/s41576-023-00645-2","article-title":"Rna modifications in physiology and\ndisease: towards clinical applications","volume":"25","author":"Delaunay","year":"2024","journal-title":"Nat.\nRev. Genet"},{"issue":"7","key":"2026081008101717400_cit3","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic rna\nmodifications\nin gene expression regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"issue":"22","key":"2026081008101717400_cit4","doi-asserted-by":"publisher","first-page":"13851","DOI":"10.3390\/ijms232213851","article-title":"Epitranscriptome:\nreview of top 25 most-studied rna modifications","volume":"23","author":"Arzumanian","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"2026081008101717400_cit5","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.70018","article-title":"The Role of 2\u2032-O-Methylation\nin Epitranscriptomic Regulation: Gene Expression, Physiological Functions\nand Applications","volume":"16","author":"Azeem","year":"2025","journal-title":"Wiley Interdiscip. Rev.: RNA"},{"issue":"3","key":"2026081008101717400_cit6","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1006\/meth.2001.1250","article-title":"Mapping\n2\u2019-o-methyl groups in ribosomal rna","volume":"25","author":"Maden","year":"2001","journal-title":"Methods"},{"key":"2026081008101717400_cit7","doi-asserted-by":"publisher","first-page":"793582","DOI":"10.3389\/fimmu.2022.793582","article-title":"Rna 2\u2019-o-methyltransferase fibrillarin facilitates virus entry\ninto macrophages through inhibiting type i interferon response","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"2026081008101717400_cit8","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1261\/rna.079970.124","article-title":"2\u2019-o-methylation (nm) in rna:\nProgress, challenges, and future directions","volume":"30","author":"Zhou","year":"2024","journal-title":"RNA"},{"issue":"3","key":"2026081008101717400_cit9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193804","article-title":"2\u2019-o-methylation\nof the mrna cap protects rnas from decapping and degradation by dxo","volume":"13","author":"Picard-Jean","year":"2018","journal-title":"PLoS One"},{"key":"2026081008101717400_cit10","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.enz.2017.03.007","article-title":"Synthesis,\nfunction, and heterogeneity of snorna-guided posttranscriptional nucleoside\nmodifications in eukaryotic ribosomal rnas","volume":"41","author":"Henras","year":"2017","journal-title":"Enzymes"},{"issue":"2","key":"2026081008101717400_cit11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/ni.1979","article-title":"Ribose 2\u2019-o-methylation provides a molecular\nsignature for the distinction of self and non-self mrna dependent\non the rna sensor mda5","volume":"12","author":"Zu\u0308st","year":"2011","journal-title":"Nat. Immunol."},{"issue":"12","key":"2026081008101717400_cit12","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1002\/humu.22897","article-title":"Defects\nin trna anticodon loop 2\u2019-o-methylation are implicated in nonsyndromic\nx-linked intellectual disability due to mutations in ftsj1","volume":"36","author":"Guy","year":"2015","journal-title":"Human Mutation"},{"issue":"2","key":"2026081008101717400_cit13","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1158\/2159-8290.CD-22-0210","article-title":"A dynamic\nrrna ribomethylome\ndrives stemness in acute myeloid leukemia","volume":"13","author":"Zhou","year":"2023","journal-title":"Cancer\nDiscovery"},{"key":"2026081008101717400_cit14","doi-asserted-by":"publisher","first-page":"199211","DOI":"10.1016\/j.virusres.2023.199211","article-title":"Coronavirus 2\u2019-o-methyltransferase:\nA promising\ntherapeutic target","volume":"336","author":"Schindewolf","year":"2023","journal-title":"Virus Res."},{"issue":"8","key":"2026081008101717400_cit15","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1261\/rna.061549.117","article-title":"High-throughput\nand site-specific\nidentification of 2\u2019-o-methylation sites using ribose oxidation\nsequencing (riboxi-seq)","volume":"23","author":"Zhu","year":"2017","journal-title":"RNA"},{"issue":"7","key":"2026081008101717400_cit16","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/nmeth.4294","article-title":"Nm-seq maps 2\u2019-o-methylation\nsites in human mrna with base precision","volume":"14","author":"Dai","year":"2017","journal-title":"Nat.\nMethods"},{"issue":"6","key":"2026081008101717400_cit17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ygeno.2016.05.003","article-title":"Identifying\n2\u2019-o-methylationation sites by integrating nucleotide chemical\nproperties and nucleotide compositions","volume":"107","author":"Chen","year":"2016","journal-title":"Genomics"},{"key":"2026081008101717400_cit18","first-page":"2394","article-title":"Deep-2\u2019-o-me: predicting\n2\u2019-o-methylation sites by convolutional neural networks","volume-title":"In 2018 40th annual international conference of the IEEE\nEngineering in Medicine and Biology Society (EMBC)","author":"Mostavi","year":"2018"},{"issue":"11","key":"2026081008101717400_cit19","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1089\/cmb.2018.0004","article-title":"irna-2om: a sequence-based\npredictor for identifying 2\u2019-o-methylation sites in homo sapiens","volume":"25","author":"Yang","year":"2018","journal-title":"J. Comput. Biol."},{"key":"2026081008101717400_cit20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtbi.2018.12.034","article-title":"irna-pseknc\n(2methyl): Identify rna\n2\u2019-o-methylation sites by convolution neural network and chou\u2019s\npseudo components","volume":"465","author":"Tahir","year":"2019","journal-title":"J. Theor. Biol."},{"key":"2026081008101717400_cit21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ymeth.2018.11.007","article-title":"Single base resolution\nmapping of 2\u2019-o-methylation\nsites in human mrna and in 3\u2032 terminal ends of small rnas","volume":"156","author":"Hsu","year":"2019","journal-title":"Methods"},{"issue":"Suppl S25","key":"2026081008101717400_cit22","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1186\/s12859-019-3265-8","article-title":"NmSEER V2.0: a prediction\ntool for 2\u2032-O-methylation\nsites based on random forest and multi-encoding combination","volume":"20","author":"Zhou","year":"2019","journal-title":"BMC Bioinf."},{"key":"2026081008101717400_cit23","doi-asserted-by":"publisher","first-page":"686894","DOI":"10.3389\/fcell.2021.686894","article-title":"Deepome: a web server\nfor the prediction of 2\u2019-o-me\nsites based on the hybrid cnn and blstm architecture","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"2026081008101717400_cit24","doi-asserted-by":"publisher","first-page":"bbab480","DOI":"10.1093\/bib\/bbab480","article-title":"Nmrf: identification of multispecies rna 2\u2019-o-methylation\nmodification sites from rna sequences","volume":"23","author":"Ao","year":"2022","journal-title":"Briefings\nBioinf."},{"issue":"3","key":"2026081008101717400_cit25","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1109\/TCBB.2023.3237769","article-title":"Bert2ome: Prediction\nof 2\u2019-o-methylation modifications from\nrna sequence by transformer architecture based on bert","volume":"20","author":"Soylu","year":"2023","journal-title":"IEEE\/ACM Trans. Comput. Biol. Bioinf."},{"key":"2026081008101717400_cit26","doi-asserted-by":"publisher","first-page":"124247","DOI":"10.1016\/j.ijbiomac.2023.124247","article-title":"i2om: Toward a better\nprediction of 2\u2019-o-methylation in human\nrna","volume":"239","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol"},{"issue":"1","key":"2026081008101717400_cit27","doi-asserted-by":"publisher","first-page":"bbad476","DOI":"10.1093\/bib\/bbad476","article-title":"H2opred: a\nrobust and efficient hybrid deep learning model for predicting 2\u2019-o-methylation\nsites in human rna","volume":"25","author":"Pham","year":"2024","journal-title":"Briefings Bioinf."},{"issue":"6","key":"2026081008101717400_cit28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305406","article-title":"Meta-2om: a multi-classifier\nmeta-model for the accurate prediction of rna 2\u2019-o-methylation\nsites in human rna","volume":"19","author":"Harun-Or-Roshid","year":"2024","journal-title":"PLoS One"},{"issue":"8","key":"2026081008101717400_cit29","doi-asserted-by":"publisher","first-page":"btaf417","DOI":"10.1093\/bioinformatics\/btaf417","article-title":"2ome-lm: predicting\n2\u2019-o-methylation sites in\nhuman rna using a pre-trained rna language model","volume":"41","author":"Liu","year":"2025","journal-title":"Bioinformatics"},{"issue":"5","key":"2026081008101717400_cit30","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/bioinformatics\/17.5.429","article-title":"Analysis of\ngenomic sequences by chaos game representation","volume":"17","author":"Almeida","year":"2001","journal-title":"Bioinformatics"},{"key":"2026081008101717400_cit31","first-page":"00300","article-title":"Interpretable rna foundation\nmodel from unannotated data for highly\naccurate rna structure and function predictions","author":"Chen","year":"2022","journal-title":"arXiv"},{"key":"2026081008101717400_cit32","first-page":"3856","article-title":"Dynamic routing\nbetween capsules","volume-title":"Advances in Neural Information\nProcessing Systems","author":"Sabour","year":"2017"},{"issue":"D1","key":"2026081008101717400_cit33","doi-asserted-by":"publisher","first-page":"D273","DOI":"10.1093\/nar\/gkad1070","article-title":"Rmbase v3.\n0: decode the landscape, mechanisms and functions of rna modifications","volume":"52","author":"Xuan","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"13","key":"2026081008101717400_cit34","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program\nfor clustering and comparing\nlarge sets of protein or nucleotide sequences","volume":"22","author":"Li","year":"2006","journal-title":"Bioinformatics"},{"issue":"3","key":"2026081008101717400_cit35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2478\/aei-2024-0010","article-title":"Interpretability\nusing\nreconstruction of capsule networks","volume":"24","author":"Vranay","year":"2024","journal-title":"Acta Electrotech.\nInform."},{"issue":"12","key":"2026081008101717400_cit36","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1038\/s41592-024-02487-0","article-title":"Accurate rna 3d structure prediction using a language model-based\ndeep learning approach","volume":"21","author":"Shen","year":"2024","journal-title":"Nat. Methods"},{"issue":"1","key":"2026081008101717400_cit37","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.1038\/s41467-025-60872-5","article-title":"Rinalmo: General-purpose\nrna language models can generalize well on structure prediction tasks","volume":"16","author":"Penic\u0301","year":"2025","journal-title":"Nat. Commun."},{"key":"2026081008101717400_cit38","first-page":"16362","article-title":"Multi-head\nattention: Collaborate\ninstead of concatenate","author":"Cordonnier","year":"2020","journal-title":"arXiv"},{"key":"2026081008101717400_cit39","doi-asserted-by":"publisher","first-page":"6263","DOI":"10.1016\/j.csbj.2021.11.008","article-title":"Chaos game representation and its applications in bioinformatics","volume":"19","author":"Lo\u0308chel","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"1","key":"2026081008101717400_cit40","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/bioinformatics\/btz493","article-title":"Deep learning on chaos\ngame representation for proteins","volume":"36","author":"Lo\u0308chel","year":"2020","journal-title":"Bioinformatics"},{"issue":"1","key":"2026081008101717400_cit41","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/j.jksuci.2019.09.014","article-title":"Capsule Networks\n\u2013 A survey","volume":"34","author":"Patrick","year":"2022","journal-title":"J. King Saud Univ. - Comput.\nInf. Sci."},{"key":"2026081008101717400_cit42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-3-030-57077-4_10","article-title":"Pytorch","volume-title":"Programming with TensorFlow:\nSolution for edge computing applications","author":"Imambi","year":"2021"},{"key":"2026081008101717400_cit43","first-page":"1","article-title":"Improved adam\noptimizer for deep neural networks","volume-title":"In 2018\nIEEE\/ACM 26th international symposium on quality of service (IWQoS)","author":"Zhang","year":"2018"},{"issue":"9","key":"2026081008101717400_cit44","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/s41422-023-00836-w","article-title":"Nm-mut-seq:\na base-resolution quantitative method for mapping transcriptome-wide\n2\u2019-o-methylation","volume":"33","author":"Chen","year":"2023","journal-title":"Cell Res."}],"container-title":["Journal of Chemical Information\nand Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.6c01274","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jcisd8\/article-pdf\/66\/15\/9651\/66258784\/acs.jcim.6c01274.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jcisd8\/article-pdf\/66\/15\/9651\/66258784\/acs.jcim.6c01274.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:20:47Z","timestamp":1786364447000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jcisd8\/article\/66\/15\/9651\/5232603\/An-Interpretable-Deep-Learning-Framework"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":44,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,6,15]]},"published-print":{"date-parts":[[2026,8,10]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.6c01274","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]}}}