{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:15:32Z","timestamp":1772806532560,"version":"3.50.1"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P30 DA035778A1"],"award-info":[{"award-number":["P30 DA035778A1"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01 DA025612"],"award-info":[{"award-number":["R01 DA025612"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-16-1-0490"],"award-info":[{"award-number":["W81XWH-16-1-0490"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2019,4,22]]},"DOI":"10.1021\/acs.jcim.8b00623","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T23:30:54Z","timestamp":1551828654000},"page":"1283-1289","source":"Crossref","is-referenced-by-count":25,"title":["DAKB-GPCRs: An Integrated Computational Platform for Drug Abuse Related GPCRs"],"prefix":"10.1021","volume":"59","author":[{"given":"Maozi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, Pennsylvania 15261, United States"},{"name":"NIH National Center of Excellence for Computational Drug Abuse Research, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Drug Discovery Institute, Pittsburgh, Pennsylvania 15261, United States"}]},{"given":"Yankang","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, Pennsylvania 15261, United States"},{"name":"NIH National Center of Excellence for Computational Drug Abuse Research, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Drug Discovery Institute, Pittsburgh, Pennsylvania 15261, United States"}]},{"given":"Lirong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, Pennsylvania 15261, United States"},{"name":"NIH National Center of Excellence for Computational Drug Abuse Research, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Drug Discovery Institute, Pittsburgh, Pennsylvania 15261, United States"}]},{"given":"Zhiwei","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, Pennsylvania 15261, United States"},{"name":"NIH National Center of Excellence for Computational Drug Abuse Research, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Drug Discovery Institute, Pittsburgh, Pennsylvania 15261, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-6175","authenticated-orcid":true,"given":"Xiang-Qun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, Pennsylvania 15261, United States"},{"name":"NIH National Center of Excellence for Computational Drug Abuse Research, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Drug Discovery Institute, Pittsburgh, Pennsylvania 15261, United States"},{"name":"Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States"}]}],"member":"316","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"ref1\/cit1","unstructured":"NIDA Nationwide Trends. https:\/\/www.drugabuse.gov\/publications\/drugfacts\/nationwide-trends (Jan 10)."},{"key":"ref2\/cit2","unstructured":"NIDA Costs of Substance\nAbuse. https:\/\/www.drugabuse.gov\/related-topics\/trends-statistics (18\nDec)."},{"key":"ref3\/cit3","volume-title":"National Drug Threat Assessment","author":"National Drug Intelligence Center (NDIC).","year":"2017"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01075.x"},{"key":"ref5\/cit5","unstructured":"Surgeon\nGeneral of the United\nStates. The Health Consequences of\nSmoking\u201450 Years of Progress: A Report of the Surgeon General; January 2014."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2014.10.012"},{"key":"ref7\/cit7","unstructured":"CDC. https:\/\/www.cdc.gov\/features\/costsofdrinking\/ (April 21)."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00003"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.6.674"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-12-800634-4.00019-6","volume-title":"Neuropathology of Drug Addictions and Substance Misuse","author":"Xie X.-Q.","year":"2016"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)91215-7"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00985"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.118"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10728"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002642"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00128"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(92)90062-B"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2004.03.009"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2016.09.009"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04288.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1549"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/ci500004h"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00748"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/srep33963"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1098"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1099"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1218"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1095"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr777"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9449-z"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.3"},{"key":"ref33\/cit33","volume-title":"SYBYL-X","year":"2010"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ci5002718"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ci5007189"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5b00739"},{"key":"ref37\/cit37","first-page":"447","volume":"20","author":"Chen K.-C.","year":"1977","journal-title":"Sci. Sin."},{"key":"ref38\/cit38","first-page":"126","volume":"18","author":"Chou K.","year":"1981","journal-title":"Chem. Scr."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360271109"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/0301-4622(88)85002-6"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(89)82676-1"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(92)90023-Y"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzp012"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(89)90026-1"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2010.06.009"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/S1093-3263(02)00123-7"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/ct200133y"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1006\/jcph.1999.6201"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21287"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-2-1"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2016.08.001"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","unstructured":"Li, H.; Leung, K.S.; Wong, M.H. idock: A multithreaded virtual screening tool for flexible ligand docking. In  2012 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB); IEEE: 2012; pp 77\u201384.","DOI":"10.1109\/CIBCB.2012.6217214"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1958.tb00292.x"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1109\/34.709601"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-101-1_3"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/ci100399j"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/ci3003914"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/ci600312d"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00121"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-5-24"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-33"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty419"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv402"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.4236\/ns.2009.12011"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21163"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2014.998710"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw539"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.2174\/1573406411666141229162834"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.8b00623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T03:00:50Z","timestamp":1682305250000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.8b00623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,5]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4,22]]}},"alternative-id":["10.1021\/acs.jcim.8b00623"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.8b00623","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,5]]}}}