{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T11:35:40Z","timestamp":1769945740252,"version":"3.49.0"},"reference-count":79,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100008394","name":"Natur og Univers, Det Frie Forskningsr?d","doi-asserted-by":"publisher","award":["7016-00079B"],"award-info":[{"award-number":["7016-00079B"]}],"id":[{"id":"10.13039\/100008394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","award":["NNF17OC0028860"],"award-info":[{"award-number":["NNF17OC0028860"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2019,2,25]]},"DOI":"10.1021\/acs.jcim.8b00896","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T21:47:46Z","timestamp":1548452866000},"page":"858-870","source":"Crossref","is-referenced-by-count":22,"title":["Computing the Pathogenicity of Alzheimer\u2019s Disease Presenilin 1 Mutations"],"prefix":"10.1021","volume":"59","author":[{"given":"Ning","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9726-8454","authenticated-orcid":true,"given":"Budheswar","family":"Dehury","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6754-7348","authenticated-orcid":true,"given":"Kasper P.","family":"Kepp","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark"}]}],"member":"316","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002369"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.117"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042915-103753"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1177\/0891988710383571"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt59"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1126\/science.2880399"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/375754a0"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/ng1292-330"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/ng1292-335"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.7.985"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25806"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22117"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80230-5"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00187-1"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.06.004"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2006-9S317"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.264473"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035133"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.018"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03578.x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00182-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608332104"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13535"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.06.1895"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618657114"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180829"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/srep19848"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002270"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619574114"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-061516-045115"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr363"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2008.12.3904"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)01988-0"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5255"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2015.01.003"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22770"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.07.014"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066273"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv625"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.11.988"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1110\/ps.30001"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00208"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000596"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nature14892"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1002\/msb.20145092"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12814"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki387"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00442-4"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.7b00125"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22921"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku411"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki375"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1028"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt691"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx439"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-151"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/srep23257"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2016.01.012"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg509"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx313"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-S3-S2"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl423"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn435"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1101\/gr.772403"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv195"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22225"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22531-2"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1541-z"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201700467"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006739"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.03.069"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00537"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.02.008"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0167-z"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.8b00896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T21:25:54Z","timestamp":1681766754000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.8b00896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,25]]}},"alternative-id":["10.1021\/acs.jcim.8b00896"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.8b00896","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,25]]}}}